N-Acylation Reactions of Amines

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14 Citations (Scopus)


The amide bond is ubiquitous throughout chemistry and is found throughout biology, medicinal chemistry, and materials science. As a consequence, methods for the N-acylation of amines to form amides is one of the most widely researched reactions in organic chemistry. This update describes the most widely used N-acylation reactions used for the preparation of secondary and tertiary amides using a variety of acylating agents, including peptide bond-forming reactions used for the synthesis of large polypeptide chains. The latest developments in N-acylation reactions are also highlighted, in particular, advances in catalytic approaches to amide bonds, chemical ligation of peptides, as well as effective N-acylation strategies that have been employed for the kinetic resolution of racemic amines.

Original languageEnglish
Title of host publicationComprehensive Organic Synthesis II
Number of pages52
ISBN (Print)9780080977430
Publication statusPublished - 2014

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    Taylor, J. E., & Bull, S. D. (2014). N-Acylation Reactions of Amines. In Comprehensive Organic Synthesis II (2 ed., Vol. 6, pp. 427-478). Elsevier. https://doi.org/10.1016/B978-0-08-097742-3.00617-0