N-Acylation Reactions of Amines

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

The amide bond is ubiquitous throughout chemistry and is found throughout biology, medicinal chemistry, and materials science. As a consequence, methods for the N-acylation of amines to form amides is one of the most widely researched reactions in organic chemistry. This update describes the most widely used N-acylation reactions used for the preparation of secondary and tertiary amides using a variety of acylating agents, including peptide bond-forming reactions used for the synthesis of large polypeptide chains. The latest developments in N-acylation reactions are also highlighted, in particular, advances in catalytic approaches to amide bonds, chemical ligation of peptides, as well as effective N-acylation strategies that have been employed for the kinetic resolution of racemic amines.

Original languageEnglish
Title of host publicationComprehensive Organic Synthesis II
PublisherElsevier
Pages427-478
Number of pages52
Volume6
Edition2
ISBN (Print)9780080977430
DOIs
Publication statusPublished - 2014

Fingerprint

Acylation
Amides
Amines
Peptides
Chemical bonds
Materials science
Kinetics

Cite this

Taylor, J. E., & Bull, S. D. (2014). N-Acylation Reactions of Amines. In Comprehensive Organic Synthesis II (2 ed., Vol. 6, pp. 427-478). Elsevier. https://doi.org/10.1016/B978-0-08-097742-3.00617-0

N-Acylation Reactions of Amines. / Taylor, J.E.; Bull, S.D.

Comprehensive Organic Synthesis II. Vol. 6 2. ed. Elsevier, 2014. p. 427-478.

Research output: Chapter in Book/Report/Conference proceedingChapter

Taylor, JE & Bull, SD 2014, N-Acylation Reactions of Amines. in Comprehensive Organic Synthesis II. 2 edn, vol. 6, Elsevier, pp. 427-478. https://doi.org/10.1016/B978-0-08-097742-3.00617-0
Taylor JE, Bull SD. N-Acylation Reactions of Amines. In Comprehensive Organic Synthesis II. 2 ed. Vol. 6. Elsevier. 2014. p. 427-478 https://doi.org/10.1016/B978-0-08-097742-3.00617-0
Taylor, J.E. ; Bull, S.D. / N-Acylation Reactions of Amines. Comprehensive Organic Synthesis II. Vol. 6 2. ed. Elsevier, 2014. pp. 427-478
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