N-Acylation Reactions of Amines

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Abstract

The amide bond is ubiquitous throughout chemistry and is found throughout biology, medicinal chemistry, and materials science. As a consequence, methods for the N-acylation of amines to form amides is one of the most widely researched reactions in organic chemistry. This update describes the most widely used N-acylation reactions used for the preparation of secondary and tertiary amides using a variety of acylating agents, including peptide bond-forming reactions used for the synthesis of large polypeptide chains. The latest developments in N-acylation reactions are also highlighted, in particular, advances in catalytic approaches to amide bonds, chemical ligation of peptides, as well as effective N-acylation strategies that have been employed for the kinetic resolution of racemic amines.

Original languageEnglish
Title of host publicationComprehensive Organic Synthesis II
PublisherElsevier
Pages427-478
Number of pages52
Volume6
Edition2
ISBN (Print)9780080977430
DOIs
Publication statusPublished - 2014

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