Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis

Pak-Leung Ho; Melissa Chun-Jiao Liu; Kin-Hung Chow; Cindy Wing-Sze Tse; Wai-U Lo; Siu-Ka Mak; Wai-Kei Lo

doi:10.1128/AAC.00948-16

Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis

Pak-Leung Ho, Melissa Chun-Jiao Liu, Kin-Hung Chow, Cindy Wing-Sze Tse, Wai-U Lo, Siu-Ka Mak, Wai-Kei Lo

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (SciVal)

Abstract

Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants.

Original language	English
Pages (from-to)	6411-4
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00948-16
Publication status	Published - Oct 2016

Bibliographical note

Keywords

Drug Resistance, Multiple, Bacterial/drug effects
Genes, Bacterial
Hong Kong
Humans
Methicillin Resistance/genetics
Microbial Sensitivity Tests
Mupirocin/pharmacology
Mutation
Plasmids
Staphylococcus lugdunensis/drug effects

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title = "Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis",

abstract = "Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants.",

keywords = "Drug Resistance, Multiple, Bacterial/drug effects, Genes, Bacterial, Hong Kong, Humans, Methicillin Resistance/genetics, Microbial Sensitivity Tests, Mupirocin/pharmacology, Mutation, Plasmids, Staphylococcus lugdunensis/drug effects",

author = "Pak-Leung Ho and Liu, {Melissa Chun-Jiao} and Kin-Hung Chow and Tse, {Cindy Wing-Sze} and Wai-U Lo and Siu-Ka Mak and Wai-Kei Lo",

year = "2016",

month = oct,

doi = "10.1128/AAC.00948-16",

language = "English",

volume = "60",

pages = "6411--4",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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}

TY - JOUR

T1 - Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis

AU - Ho, Pak-Leung

AU - Liu, Melissa Chun-Jiao

AU - Chow, Kin-Hung

AU - Tse, Cindy Wing-Sze

AU - Lo, Wai-U

AU - Mak, Siu-Ka

AU - Lo, Wai-Kei

PY - 2016/10

Y1 - 2016/10

N2 - Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants.

AB - Of 137 Staphylococcus lugdunensis isolates collected from two nephrology centers in Hong Kong, 10 (7.3%) and 3 (2.2%) isolates had high-level and low-level mupirocin resistance, respectively. Isolates with high-level resistance contained the plasmid-mediated ileS2 gene, while isolates with low-level resistance contained the mutation V588F within the chromosomal ileS gene. All but one of the ileS2-positive isolates belong to the predominating clone HKU1. Plasmids carrying the ileS2 gene were mosaic and also cocarry multiple other resistance determinants.

KW - Drug Resistance, Multiple, Bacterial/drug effects

KW - Genes, Bacterial

KW - Hong Kong

KW - Humans

KW - Methicillin Resistance/genetics

KW - Microbial Sensitivity Tests

KW - Mupirocin/pharmacology

KW - Mutation

KW - Plasmids

KW - Staphylococcus lugdunensis/drug effects

U2 - 10.1128/AAC.00948-16

DO - 10.1128/AAC.00948-16

M3 - Article

C2 - 27503649

SN - 0066-4804

VL - 60

SP - 6411

EP - 6414

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

ER -

Emergence of ileS2-Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis

Abstract

Bibliographical note

Keywords

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