Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

Nikhil Bhalla, Wen Yaw Danny Chung, Kerwin Wang, Teddy Lessmana, P Estrela

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.
Original languageEnglish
Title of host publication2013 IEEE Sensors Proceedings
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages310-313
Number of pages4
ISBN (Electronic)9781467346429
DOIs
Publication statusPublished - 2013
EventIEEE Sensors 2013 - Baltimore, MD, USA United States
Duration: 3 Nov 20136 Nov 2013

Conference

ConferenceIEEE Sensors 2013
CountryUSA United States
CityBaltimore, MD
Period3/11/136/11/13

Fingerprint

Digital microfluidics
Washing
Microelectrodes
Magnets
Field programmable gate arrays (FPGA)
Labels
Electric fields
Magnetic fields
Fabrication
Electrodes
Sensors

Cite this

Bhalla, N., Danny Chung, W. Y., Wang, K., Lessmana, T., & Estrela, P. (2013). Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing. In 2013 IEEE Sensors Proceedings (pp. 310-313). Piscataway, NJ: IEEE. https://doi.org/10.1109/ICSENS.2013.6688201

Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing. / Bhalla, Nikhil; Danny Chung, Wen Yaw; Wang, Kerwin; Lessmana, Teddy; Estrela, P.

2013 IEEE Sensors Proceedings. Piscataway, NJ : IEEE, 2013. p. 310-313.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bhalla, N, Danny Chung, WY, Wang, K, Lessmana, T & Estrela, P 2013, Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing. in 2013 IEEE Sensors Proceedings. IEEE, Piscataway, NJ, pp. 310-313, IEEE Sensors 2013, Baltimore, MD, USA United States, 3/11/13. https://doi.org/10.1109/ICSENS.2013.6688201
Bhalla N, Danny Chung WY, Wang K, Lessmana T, Estrela P. Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing. In 2013 IEEE Sensors Proceedings. Piscataway, NJ: IEEE. 2013. p. 310-313 https://doi.org/10.1109/ICSENS.2013.6688201
Bhalla, Nikhil ; Danny Chung, Wen Yaw ; Wang, Kerwin ; Lessmana, Teddy ; Estrela, P. / Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing. 2013 IEEE Sensors Proceedings. Piscataway, NJ : IEEE, 2013. pp. 310-313
@inproceedings{37bd369240354048967e2deda563908a,
title = "Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing",
abstract = "This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.",
author = "Nikhil Bhalla and {Danny Chung}, {Wen Yaw} and Kerwin Wang and Teddy Lessmana and P Estrela",
year = "2013",
doi = "10.1109/ICSENS.2013.6688201",
language = "English",
pages = "310--313",
booktitle = "2013 IEEE Sensors Proceedings",
publisher = "IEEE",
address = "USA United States",

}

TY - GEN

T1 - Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

AU - Bhalla, Nikhil

AU - Danny Chung, Wen Yaw

AU - Wang, Kerwin

AU - Lessmana, Teddy

AU - Estrela, P

PY - 2013

Y1 - 2013

N2 - This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

AB - This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

UR - http://dx.doi.org/10.1109/ICSENS.2013.6688201

U2 - 10.1109/ICSENS.2013.6688201

DO - 10.1109/ICSENS.2013.6688201

M3 - Conference contribution

SP - 310

EP - 313

BT - 2013 IEEE Sensors Proceedings

PB - IEEE

CY - Piscataway, NJ

ER -