Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

Nikhil Bhalla; Wen Yaw Danny Chung; Kerwin Wang; Teddy Lessmana; P Estrela

doi:10.1109/ICSENS.2013.6688201

Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

Nikhil Bhalla, Wen Yaw Danny Chung, Kerwin Wang, Teddy Lessmana, P Estrela

Department of Electronic & Electrical Engineering

Chung Yuan Christian University

Research output: Chapter or section in a book/report/conference proceeding › Chapter in a published conference proceeding

Abstract

This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

Original language	English
Title of host publication	2013 IEEE Sensors Proceedings
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	310-313
Number of pages	4
ISBN (Electronic)	9781467346429
DOIs	https://doi.org/10.1109/ICSENS.2013.6688201
Publication status	Published - 2013
Event	IEEE Sensors 2013 - Baltimore, MD, USA United States Duration: 3 Nov 2013 → 6 Nov 2013

Conference

Conference	IEEE Sensors 2013
Country/Territory	USA United States
City	Baltimore, MD
Period	3/11/13 → 6/11/13

Access to Document

10.1109/ICSENS.2013.6688201

Cite this

@inproceedings{37bd369240354048967e2deda563908a,

title = "Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing",

abstract = "This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.",

author = "Nikhil Bhalla and {Danny Chung}, {Wen Yaw} and Kerwin Wang and Teddy Lessmana and P Estrela",

year = "2013",

doi = "10.1109/ICSENS.2013.6688201",

language = "English",

pages = "310--313",

booktitle = "2013 IEEE Sensors Proceedings",

publisher = "IEEE",

address = "USA United States",

note = "IEEE Sensors 2013 ; Conference date: 03-11-2013 Through 06-11-2013",

}

TY - GEN

T1 - Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

AU - Bhalla, Nikhil

AU - Danny Chung, Wen Yaw

AU - Wang, Kerwin

AU - Lessmana, Teddy

AU - Estrela, P

PY - 2013

Y1 - 2013

N2 - This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

AB - This work demonstrates a unique DMF (Digital Microfluidics) immunoassay chip with 17 microelectrodes in an area of 6×6 mm2, which manipulates both electric and magnetic fields, to carry magnetic particle based immunoassay. Superparamagentic particles act as a label for the analyte in measurement and Hall sensor response indicates the presence of target analyte. This report describes magnetic washing (pulling of unbound magnetic beads) on DMF chip without any external magnet or additional component. The chip has a novel fabrication process where 600×600 micron electrodes are interspaced with a gap of 22 micron. The movement of the droplet on the chip is controlled automatically by using FPGA Altera DE0.

UR - http://dx.doi.org/10.1109/ICSENS.2013.6688201

U2 - 10.1109/ICSENS.2013.6688201

DO - 10.1109/ICSENS.2013.6688201

M3 - Chapter in a published conference proceeding

SP - 310

EP - 313

BT - 2013 IEEE Sensors Proceedings

PB - IEEE

CY - Piscataway, NJ

T2 - IEEE Sensors 2013

Y2 - 3 November 2013 through 6 November 2013

ER -

Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing

Abstract

Conference

Access to Document

Other files and links

Fingerprint

Cite this