Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal

Robert D. Crapnell; Huda S. Alhasan; Lee I. Partington; Yan Zhou; Ziauddin Ahmed; Amal A. Atalhi; Thomas S. Varley; Nadiya Alahmadi; Georg H. Mehl; Stephen M. Kelly; Nathan S. Lawrence; Frank Marken; Jay D Wadhawan

doi:10.1021/acsomega.0c05284

Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal

Robert D. Crapnell, Huda S. Alhasan, Lee I. Partington, Yan Zhou, Ziauddin Ahmed, Amal A. Atalhi, Thomas S. Varley, Nadiya Alahmadi, Georg H. Mehl, Stephen M. Kelly, Nathan S. Lawrence, Frank Marken, Jay D Wadhawan

Research output: Contribution to journal › Article › peer-review

2 Citations (SciVal)

Abstract

The discovery of electrochemical switching of the Lα phase of chlorpromazine hydrochloride in water is reported. The phase is characterized using polarizing microscopy, X-ray scattering, rheological measurements, and microelectrode voltammetry. Fast, heterogeneous oxidation of the lyotropic liquid crystal is shown to cause a phase change resulting from the disordering of the structural order in a stepwise process. The underlying molecular dynamics is considered to be a cooperative effect of both increasing electrostatic interactions and an unfolding of the monomers from “butterfly”-shaped in the reduced form to planar in the oxidized form.

Original language	English
Pages (from-to)	4630-4640
Number of pages	11
Journal	ACS OMEGA
Volume	6
Issue number	7
Early online date	5 Feb 2021
DOIs	https://doi.org/10.1021/acsomega.0c05284
Publication status	Published - 23 Feb 2021

Funding

The authors thank EPSRC (GR/N EP/G020833/1) and The University of Hull for financing this work. G.H.M. thanks EPSRC (GR/N EP/M015726/1) for funding. H.S.A. thanks the Iraqi Cultural Attache for financing her Ph.D. and The University of Babylon for further support. Y.Z. thanks China University of Petroleum for further funding. A.A.A. thanks the Royal Kingdom of Saudi Arabia for funding her Ph.D. and Taif University for further support. N.A. thanks The University of Jeddah for financial support. F.M. and J.D.W. thank Jon Mitchell (University of Bath) for undertaking TEM measurements. H.S.A. and J.D.W. thank Tim Dunstan (University of Hull) for undertaking rheological measurements. The contribution of Laurence Boulder, James Shellbourne, Laetita Testut, Håvard Eide, Haydn Ward, Adam Gregory, and Akalya Raviraj in repeating various aspects of this work is also acknowledged.

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Crapnell, R. D., Alhasan, H. S., Partington, L. I., Zhou, Y., Ahmed, Z., Atalhi, A. A., Varley, T. S., Alahmadi, N., Mehl, G. H., Kelly, S. M., Lawrence, N. S., Marken, F., & Wadhawan, J. D. (2021). Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal. ACS OMEGA, 6(7), 4630-4640. https://doi.org/10.1021/acsomega.0c05284

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abstract = "The discovery of electrochemical switching of the Lα phase of chlorpromazine hydrochloride in water is reported. The phase is characterized using polarizing microscopy, X-ray scattering, rheological measurements, and microelectrode voltammetry. Fast, heterogeneous oxidation of the lyotropic liquid crystal is shown to cause a phase change resulting from the disordering of the structural order in a stepwise process. The underlying molecular dynamics is considered to be a cooperative effect of both increasing electrostatic interactions and an unfolding of the monomers from “butterfly”-shaped in the reduced form to planar in the oxidized form.",

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AU - Zhou, Yan

AU - Ahmed, Ziauddin

AU - Atalhi, Amal A.

AU - Varley, Thomas S.

AU - Alahmadi, Nadiya

AU - Mehl, Georg H.

AU - Kelly, Stephen M.

AU - Lawrence, Nathan S.

AU - Marken, Frank

AU - Wadhawan, Jay D

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AB - The discovery of electrochemical switching of the Lα phase of chlorpromazine hydrochloride in water is reported. The phase is characterized using polarizing microscopy, X-ray scattering, rheological measurements, and microelectrode voltammetry. Fast, heterogeneous oxidation of the lyotropic liquid crystal is shown to cause a phase change resulting from the disordering of the structural order in a stepwise process. The underlying molecular dynamics is considered to be a cooperative effect of both increasing electrostatic interactions and an unfolding of the monomers from “butterfly”-shaped in the reduced form to planar in the oxidized form.

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DO - 10.1021/acsomega.0c05284

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EP - 4640

JO - ACS OMEGA

JF - ACS OMEGA

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Electrochemically Induced Mesomorphism Switching in a Chlorpromazine Hydrochloride Lyotropic Liquid Crystal

Abstract

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