Abstract
Organophosphorus chemistry is a broad field with multi-dimensional applications in research area of organic, biology, drug design and agrochemicals. Conventional methods have been adopted extensively to access phosphorylated compounds that rely on the use of toxic, moisture sensitive phosphorylating agents and occur in the presence of oxidants, catalysts, as well as high temperatures and harsh conditions are required for complete transformations. However, recent progress has been made for phosphorylation reactions using electricity to introduce green and sustainable synthetic procedures. These reactions can be performed at mild conditions and proceed with excellent atom economy. Herein, we targeted electrochemical phosphorylation reactions with generation of new bonds such as C(sp3) −P, C(sp2) −P, O−P, N−P, S−P and Se−P. This review is aimed to offer an overview of recent developments in the synthetic methodology to easy access of organophosphorus compounds using electrochemistry.
| Original language | English |
|---|---|
| Pages (from-to) | 1530-1552 |
| Journal | Chemical Record |
| Volume | 20 |
| Issue number | 12 |
| Early online date | 5 Oct 2020 |
| DOIs | |
| Publication status | Published - 1 Dec 2020 |
Funding
.. We also thank to RUDN University 5–100 Project framework Program (N.S), Daphne Jackson fellowship (B.S), CNPq (G.M.M) for their funding support. Thanks to Geórgia C. Zimmer for her contribution to TOC. Support from the Marie Curie EU‐COFUND Fellowship (Grant No 663830) to Dr. Nisar Ahmed is gratefully acknowledged . obtained his Ph.D in organic chemistry (2012) under Brain Korea BK21 fellowship working in the group of Prof. Kwang S. Kim (POSTECH, Korea). Then, he moved to the University of Zurich, Switzerland (2013) for a postdoctoral stay with a Novartis Fellowship. Subsequently (2015), he joined the University of Bristol as a research associate. He started his research career in 2017 at School of Chemistry, Cardiff University, United Kingdom with early career EU‐COFUND grant as Sêr Cymru Fellow. However, the recent research support includes an EPSRC grant (UKRI). He is also an Adjunct faculty Professor at HEJ Research Institute of Chemistry, ICCBS since 2018. His research interests are development of green & sustainable technology in organic synthesis using batch & microflow electrochemistry and molecular recognition of biomolecules Nisar Ahmed
Keywords
- Atom economy
- Electrifying synthesis
- Green phosphorylation reactions
- Organic electrochemistry
- Organophosphorus chemistry
ASJC Scopus subject areas
- General Chemistry
- Biochemistry
- General Chemical Engineering
- Materials Chemistry