Abstract
The pyoverdine chromophore is an important component of a family of siderophores which are secreted by the human pathogen Pseudomonas aeruginosa for iron absorption. In this study, an efficient and improved synthetic route to the chromophore structure is reported, beginning from readily available starting materials, D-glutamic acid and L-DOPA. This strategy has not only delivered the first synthesis of the free pyoverdine D chromophore, but also offers potential access to a wide range of other pyoverdine chromophore species.
| Original language | English |
|---|---|
| Article number | e202400745 |
| Number of pages | 6 |
| Journal | European Journal of Organic Chemistry |
| Volume | 27 |
| Issue number | 46 |
| Early online date | 20 Sept 2024 |
| DOIs | |
| Publication status | Published - 9 Dec 2024 |
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.Funding
The authors acknowledge the Material and Chemical Characterization Facility (MC2) at the University of Bath.
| Funders | Funder number |
|---|---|
| University of Bath |
Keywords
- Chromophores
- Natural products
- Peptides
- Siderophores
- Total synthesis
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry