Efficient synthesis of tetrahydro-β-carbolin-1-one and dihydroisoquinolin-1-one derivatives as versatile intermediates

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Abstract

An efficient one-pot procedure is described in which an isocyanate intermediate, generated from the corresponding carboxylic acid by a modified Curtius rearrangement, is captured by a tethered aromatic ring in the presence of BF3 center dot OEt2 to generate various lactams, including tetrahydro-β-carbolin-1-one and dihydroisoquinolin-1-one derivatives.
Original languageEnglish
Pages (from-to)2809-2817
Number of pages9
JournalSynthesis
Volume2009
Issue number16
Early online date13 Jul 2009
DOIs
Publication statusPublished - Aug 2009

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