TY - JOUR
T1 - Efficient synthesis of tetrahydro-β-carbolin-1-one and dihydroisoquinolin-1-one derivatives as versatile intermediates
AU - Judd, K E
AU - Mahon, Mary F
AU - Caggiano, Lorenzo
PY - 2009/8
Y1 - 2009/8
N2 - An efficient one-pot procedure is described in which an isocyanate intermediate, generated from the corresponding carboxylic acid by a modified Curtius rearrangement, is captured by a tethered aromatic ring in the presence of BF3 center dot OEt2 to generate various lactams, including tetrahydro-β-carbolin-1-one and dihydroisoquinolin-1-one derivatives.
AB - An efficient one-pot procedure is described in which an isocyanate intermediate, generated from the corresponding carboxylic acid by a modified Curtius rearrangement, is captured by a tethered aromatic ring in the presence of BF3 center dot OEt2 to generate various lactams, including tetrahydro-β-carbolin-1-one and dihydroisoquinolin-1-one derivatives.
UR - http://www.scopus.com/inward/record.url?scp=70449372103&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1055/s-0029-1216904
U2 - 10.1055/s-0029-1216904
DO - 10.1055/s-0029-1216904
M3 - Article
SN - 0039-7881
VL - 2009
SP - 2809
EP - 2817
JO - Synthesis
JF - Synthesis
IS - 16
ER -