Efficient siRNA delivery and gene silencing by unsymmetrical fatty acid amides of spermine

Abdelkader A Metwally, Charareh Pourzand, Ian S Blagbrough

Research output: Contribution to journalArticle

Abstract

Gene silencing by siRNA i.e. synthetic dsRNA of 21–24 nucleotides, is already an important biological tool in the study of gene function and it also has many potential thera-peutic applications for diffi cult-to-treat diseases [1].
Long-chain fatty acid amides of the naturally occurring polyamine spermine have previously been synthesised and evaluated in our research group for both pDNA and siRNA delivery [2–5]. Our SAR studies of long- (C18) and very-long (C20 and longer) fatty acid [6] conjugates of spermine are important in investigating the enhancement of siRNA delivery and of gene silencing.

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Spermine
Gene Silencing
Amides
Small Interfering RNA
Fatty Acids
Polyamines
Nucleotides
Research
Genes

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Efficient siRNA delivery and gene silencing by unsymmetrical fatty acid amides of spermine. / Metwally, Abdelkader A; Pourzand, Charareh; Blagbrough, Ian S.

In: Journal of Pharmacy and Pharmacology, Vol. 62, No. 10, 10.2010, p. 1220-1221.

Research output: Contribution to journalArticle

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