Abstract
Gene silencing by siRNA i.e. synthetic dsRNA of 21–24 nucleotides, is already an important biological tool in the study of gene function and it also has many potential thera-peutic applications for diffi cult-to-treat diseases [1].
Long-chain fatty acid amides of the naturally occurring polyamine spermine have previously been synthesised and evaluated in our research group for both pDNA and siRNA delivery [2–5]. Our SAR studies of long- (C18) and very-long (C20 and longer) fatty acid [6] conjugates of spermine are important in investigating the enhancement of siRNA delivery and of gene silencing.
Long-chain fatty acid amides of the naturally occurring polyamine spermine have previously been synthesised and evaluated in our research group for both pDNA and siRNA delivery [2–5]. Our SAR studies of long- (C18) and very-long (C20 and longer) fatty acid [6] conjugates of spermine are important in investigating the enhancement of siRNA delivery and of gene silencing.
| Original language | English |
|---|---|
| Pages (from-to) | 1220-1221 |
| Number of pages | 2 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 62 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 2010 |
| Event | UK PharmSci 2010 - The Science of Medicines - , UK United Kingdom Duration: 1 Sept 2010 → 3 Sept 2010 |