Abstract
Microwave dielectric heating proved to be an efficient method for the one-pot and stepwise syntheses of symmetrical and unsymmetrical naphthalenediimide derivatives of alpha-amino acids. Acid-labile side chain protecting groups are stable under the reaction conditions; protection of the alpha-carboxylic group is not required. The stepwise condensation of different amino acids resulted in high yields of unsymmetrical naphthalenediimides. The reaction proceeds without racemization and is essentially quantitative.
Original language | English |
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Pages (from-to) | 7063-7066 |
Number of pages | 4 |
Journal | Journal of Organic Chemistry |
Volume | 71 |
Issue number | 18 |
DOIs | |
Publication status | Published - 1 Sept 2006 |