Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 7063-7066 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 71 |
| Issue number | 18 |
| DOIs | |
| Publication status | Published - 1 Sep 2006 |
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Efficient and mild microwave-assisted stepwise functionalization of naphthalenediimide with alpha-amino acids. / Pengo, Paolo; Pantos, G. Dan; Otto, Sijbren; Sanders, Jeremy K. M.
In: Journal of Organic Chemistry, Vol. 71, No. 18, 01.09.2006, p. 7063-7066.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Efficient and mild microwave-assisted stepwise functionalization of naphthalenediimide with alpha-amino acids
AU - Pengo, Paolo
AU - Pantos, G. Dan
AU - Otto, Sijbren
AU - Sanders, Jeremy K. M.
PY - 2006/9/1
Y1 - 2006/9/1
N2 - Microwave dielectric heating proved to be an efficient method for the one-pot and stepwise syntheses of symmetrical and unsymmetrical naphthalenediimide derivatives of alpha-amino acids. Acid-labile side chain protecting groups are stable under the reaction conditions; protection of the alpha-carboxylic group is not required. The stepwise condensation of different amino acids resulted in high yields of unsymmetrical naphthalenediimides. The reaction proceeds without racemization and is essentially quantitative.
AB - Microwave dielectric heating proved to be an efficient method for the one-pot and stepwise syntheses of symmetrical and unsymmetrical naphthalenediimide derivatives of alpha-amino acids. Acid-labile side chain protecting groups are stable under the reaction conditions; protection of the alpha-carboxylic group is not required. The stepwise condensation of different amino acids resulted in high yields of unsymmetrical naphthalenediimides. The reaction proceeds without racemization and is essentially quantitative.
U2 - 10.1021/jo061195h
DO - 10.1021/jo061195h
M3 - Article
VL - 71
SP - 7063
EP - 7066
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 18
ER -