Effects of Various Vehicles on Skin Hydration in vivo

S Wiedersberg, C S Leopold, Richard H Guy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The stratum corneum, the outermost layer of the skin, regulates the passive loss of water to the environment. Furthermore, it is well accepted that drug penetration is influenced by skin hydration, which may be manipulated by the application of moisturizing or oleaginous vehicles. Measurements of transepidermal water loss (TEWL), and of skin hydration using a corneometer, were used to assess the effect of different vehicles on stratum corneum barrier function in vivo in human volunteers. A microemulsion significantly increased skin hydration relative to a reference vehicle based on medium chain triglycerides; in contrast, Transcutol (R) lowered skin hydration. TEWL measurements confirmed these observations.
Original languageEnglish
Pages (from-to)128-130
Number of pages3
JournalSkin Pharmacology and Physiology
Volume22
Issue number3
DOIs
Publication statusPublished - 2009

Fingerprint

Skin
Cornea
Water
Volunteers
Triglycerides
Pharmaceutical Preparations

Keywords

  • Stratum corneum
  • Transepidermal water loss
  • Skin hydration
  • Vehicle effects
  • Transcutol
  • Microemulsion

Cite this

Effects of Various Vehicles on Skin Hydration in vivo. / Wiedersberg, S; Leopold, C S; Guy, Richard H.

In: Skin Pharmacology and Physiology, Vol. 22, No. 3, 2009, p. 128-130.

Research output: Contribution to journalArticle

Wiedersberg, S ; Leopold, C S ; Guy, Richard H. / Effects of Various Vehicles on Skin Hydration in vivo. In: Skin Pharmacology and Physiology. 2009 ; Vol. 22, No. 3. pp. 128-130.
@article{9de3c477ab854be299f96444600dc8fd,
title = "Effects of Various Vehicles on Skin Hydration in vivo",
abstract = "The stratum corneum, the outermost layer of the skin, regulates the passive loss of water to the environment. Furthermore, it is well accepted that drug penetration is influenced by skin hydration, which may be manipulated by the application of moisturizing or oleaginous vehicles. Measurements of transepidermal water loss (TEWL), and of skin hydration using a corneometer, were used to assess the effect of different vehicles on stratum corneum barrier function in vivo in human volunteers. A microemulsion significantly increased skin hydration relative to a reference vehicle based on medium chain triglycerides; in contrast, Transcutol (R) lowered skin hydration. TEWL measurements confirmed these observations.",
keywords = "Stratum corneum, Transepidermal water loss, Skin hydration, Vehicle effects, Transcutol, Microemulsion",
author = "S Wiedersberg and Leopold, {C S} and Guy, {Richard H}",
year = "2009",
doi = "10.1159/000189801",
language = "English",
volume = "22",
pages = "128--130",
journal = "Skin Pharmacology and Physiology",
issn = "1660-5527",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Effects of Various Vehicles on Skin Hydration in vivo

AU - Wiedersberg, S

AU - Leopold, C S

AU - Guy, Richard H

PY - 2009

Y1 - 2009

N2 - The stratum corneum, the outermost layer of the skin, regulates the passive loss of water to the environment. Furthermore, it is well accepted that drug penetration is influenced by skin hydration, which may be manipulated by the application of moisturizing or oleaginous vehicles. Measurements of transepidermal water loss (TEWL), and of skin hydration using a corneometer, were used to assess the effect of different vehicles on stratum corneum barrier function in vivo in human volunteers. A microemulsion significantly increased skin hydration relative to a reference vehicle based on medium chain triglycerides; in contrast, Transcutol (R) lowered skin hydration. TEWL measurements confirmed these observations.

AB - The stratum corneum, the outermost layer of the skin, regulates the passive loss of water to the environment. Furthermore, it is well accepted that drug penetration is influenced by skin hydration, which may be manipulated by the application of moisturizing or oleaginous vehicles. Measurements of transepidermal water loss (TEWL), and of skin hydration using a corneometer, were used to assess the effect of different vehicles on stratum corneum barrier function in vivo in human volunteers. A microemulsion significantly increased skin hydration relative to a reference vehicle based on medium chain triglycerides; in contrast, Transcutol (R) lowered skin hydration. TEWL measurements confirmed these observations.

KW - Stratum corneum

KW - Transepidermal water loss

KW - Skin hydration

KW - Vehicle effects

KW - Transcutol

KW - Microemulsion

UR - http://www.scopus.com/inward/record.url?scp=58149240229&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1159/000189801

U2 - 10.1159/000189801

DO - 10.1159/000189801

M3 - Article

VL - 22

SP - 128

EP - 130

JO - Skin Pharmacology and Physiology

JF - Skin Pharmacology and Physiology

SN - 1660-5527

IS - 3

ER -