Effects of phosphoinositides and their derivatives on membrane morphology and function

Banafshé Larijani, Dominic L. Poccia

Research output: Chapter or section in a book/report/conference proceedingChapter or section

7 Citations (SciVal)


Currently, one of the fundamental problems in the study of membrane function and morphology is that the roles of proteins and lipids are usually investigated separately. In most cases proteins are predominant, with lipids taking a subsidiary role. This polarised view is in part due to the more straightforward and familiar techniques used to investigate proteins. Here, we summarise how phospholipids can be studied in cells with new tools that can acutely (rapidly and specifically) modify phospholipid composition of membranes in subcellular compartments. We point out some of the important physical effects that phosphoinositides in particular can have in altering membrane bilayer morphology, and provide specific examples to illustrate the roles that these phospholipids may play in maintaining the geometry of endomembranes.

Original languageEnglish
Title of host publicationPhosphoinositides and Disease
PublisherSpringer Verlag
Number of pages12
ISBN (Print)9789400750241
Publication statusPublished - 20 Oct 2012

Publication series

NameCurrent Topics in Microbiology and Immunology
ISSN (Print)0070-217X

Bibliographical note

Funding Information:
BL was supported by core funding to London Research Institute from Cancer Research UK. DLP was supported by an Amherst College Faculty Research Award from the H. Axel Schupf’57 Fund for Intellectual Life.

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


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