Effects of phosphoinositides and their derivatives on membrane morphology and function

Banafshé Larijani; Dominic L. Poccia

doi:10.1007/978-94-007-5025-8_5

Effects of phosphoinositides and their derivatives on membrane morphology and function

Banafshé Larijani, Dominic L. Poccia

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

8 Citations (SciVal)

Abstract

Currently, one of the fundamental problems in the study of membrane function and morphology is that the roles of proteins and lipids are usually investigated separately. In most cases proteins are predominant, with lipids taking a subsidiary role. This polarised view is in part due to the more straightforward and familiar techniques used to investigate proteins. Here, we summarise how phospholipids can be studied in cells with new tools that can acutely (rapidly and specifically) modify phospholipid composition of membranes in subcellular compartments. We point out some of the important physical effects that phosphoinositides in particular can have in altering membrane bilayer morphology, and provide specific examples to illustrate the roles that these phospholipids may play in maintaining the geometry of endomembranes.

Original language	English
Title of host publication	Phosphoinositides and Disease
Publisher	Springer Verlag
Pages	99-110
Number of pages	12
ISBN (Print)	9789400750241
DOIs	https://doi.org/10.1007/978-94-007-5025-8_5
Publication status	Published - 20 Oct 2012

Publication series

Name	Current Topics in Microbiology and Immunology
Volume	362
ISSN (Print)	0070-217X

Bibliographical note

Funding Information:
BL was supported by core funding to London Research Institute from Cancer Research UK. DLP was supported by an Amherst College Faculty Research Award from the H. Axel Schupf’57 Fund for Intellectual Life.

Funding

BL was supported by core funding to London Research Institute from Cancer Research UK. DLP was supported by an Amherst College Faculty Research Award from the H. Axel Schupf’57 Fund for Intellectual Life.

ASJC Scopus subject areas

Immunology and Allergy
Microbiology
Immunology
Microbiology (medical)

Access to Document

10.1007/978-94-007-5025-8_5

Cite this

@inbook{8a0d140f238343388a7a372ee0f2a933,

title = "Effects of phosphoinositides and their derivatives on membrane morphology and function",

abstract = "Currently, one of the fundamental problems in the study of membrane function and morphology is that the roles of proteins and lipids are usually investigated separately. In most cases proteins are predominant, with lipids taking a subsidiary role. This polarised view is in part due to the more straightforward and familiar techniques used to investigate proteins. Here, we summarise how phospholipids can be studied in cells with new tools that can acutely (rapidly and specifically) modify phospholipid composition of membranes in subcellular compartments. We point out some of the important physical effects that phosphoinositides in particular can have in altering membrane bilayer morphology, and provide specific examples to illustrate the roles that these phospholipids may play in maintaining the geometry of endomembranes.",

author = "Banafsh{\'e} Larijani and Poccia, {Dominic L.}",

note = "Funding Information: BL was supported by core funding to London Research Institute from Cancer Research UK. DLP was supported by an Amherst College Faculty Research Award from the H. Axel Schupf{\textquoteright}57 Fund for Intellectual Life.",

year = "2012",

month = oct,

day = "20",

doi = "10.1007/978-94-007-5025-8_5",

language = "English",

isbn = "9789400750241",

series = "Current Topics in Microbiology and Immunology",

publisher = "Springer Verlag",

pages = "99--110",

booktitle = "Phosphoinositides and Disease",

}

TY - CHAP

T1 - Effects of phosphoinositides and their derivatives on membrane morphology and function

AU - Larijani, Banafshé

AU - Poccia, Dominic L.

N1 - Funding Information: BL was supported by core funding to London Research Institute from Cancer Research UK. DLP was supported by an Amherst College Faculty Research Award from the H. Axel Schupf’57 Fund for Intellectual Life.

PY - 2012/10/20

Y1 - 2012/10/20

N2 - Currently, one of the fundamental problems in the study of membrane function and morphology is that the roles of proteins and lipids are usually investigated separately. In most cases proteins are predominant, with lipids taking a subsidiary role. This polarised view is in part due to the more straightforward and familiar techniques used to investigate proteins. Here, we summarise how phospholipids can be studied in cells with new tools that can acutely (rapidly and specifically) modify phospholipid composition of membranes in subcellular compartments. We point out some of the important physical effects that phosphoinositides in particular can have in altering membrane bilayer morphology, and provide specific examples to illustrate the roles that these phospholipids may play in maintaining the geometry of endomembranes.

AB - Currently, one of the fundamental problems in the study of membrane function and morphology is that the roles of proteins and lipids are usually investigated separately. In most cases proteins are predominant, with lipids taking a subsidiary role. This polarised view is in part due to the more straightforward and familiar techniques used to investigate proteins. Here, we summarise how phospholipids can be studied in cells with new tools that can acutely (rapidly and specifically) modify phospholipid composition of membranes in subcellular compartments. We point out some of the important physical effects that phosphoinositides in particular can have in altering membrane bilayer morphology, and provide specific examples to illustrate the roles that these phospholipids may play in maintaining the geometry of endomembranes.

UR - http://www.scopus.com/inward/record.url?scp=84870040467&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-5025-8_5

DO - 10.1007/978-94-007-5025-8_5

M3 - Book chapter

C2 - 23086415

AN - SCOPUS:84870040467

SN - 9789400750241

T3 - Current Topics in Microbiology and Immunology

SP - 99

EP - 110

BT - Phosphoinositides and Disease

PB - Springer Verlag

ER -

Effects of phosphoinositides and their derivatives on membrane morphology and function

Abstract

Publication series

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this