Vernonia amygdalina leaf has a significant importance in food and traditional medicine. It has been reported to possess various pharmacological effects. This study was carried out to investigate the influence of microwave-assisted extraction factors on the extraction from V. amygdalina leaves. The results highlighted that an increase in temperature deteriorated the yields of V. amygdalina leaf. Thus, shade-dried samples gave the highest yields at the irradiation times of 10 and 2 min, microwave power of 500 and 600 W, the temperature of 100 and 80°C, the feed-to-solvent ratio of 1:10, and ethanol concentration of 60% v/v using water and ethanol as the extracting solvents, respectively. Likewise, the antioxidant assay resulted in IC50 values of 260±1.1 ?g/mL DPPH and 149.78±0.81?g/mL ABTS for water and 204±0.92?g/mL DPPH and 31.17±1.4?g/mL ABTS for ethanol. Therefore, the synergistic mechanism of mass and heat transfer may be accounted for the accelerated extraction due to microwave energy.
|Journal||Jundishapur Journal of Natural Pharmaceutical Products|
|Early online date||9 Dec 2018|
|Publication status||E-pub ahead of print - 9 Dec 2018|
- Vernonia amygdalina
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)