Effects of FMRFamide-related peptides and morphine on the isolated foregut of the locust Schistocerca gregaria

S J Wood; R H Osborne; S E Banner; K J Cattell

doi:10.1016/0742-8413(92)90014-x

Effects of FMRFamide-related peptides and morphine on the isolated foregut of the locust Schistocerca gregaria

S J Wood, R H Osborne, S E Banner, K J Cattell

Research output: Contribution to journal › Article › peer-review

Abstract

1. Morphine and YAGFMamide were the most effective potentiators of 5-hydroxytryptamine (5-HT)-induced relaxation of the isolated foregut. 2. Morphine had no effect on proctolin-induced tissue contraction which was inhibited by YGGFMamide and YFMRFamide. 3. The differing potency of FaRPs and morphine to potentiate 5-HT effects and reduce proctolin responses suggests that there are two separate FaRP receptor sub types. 4. This proposal is supported by the observation that, while naloxone (10(-5) M) is a relatively potent antagonist of FaRP induced inhibition of proctolin contraction, it has less effect on FaRP-induced potentiation of 5-HT-induced relaxation.

Original language	English
Pages (from-to)	315-20
Number of pages	6
Journal	Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
Volume	103
Issue number	2
DOIs	https://doi.org/10.1016/0742-8413(92)90014-x
Publication status	Published - Oct 1992

Keywords

Amino Acid Sequence
Animals
Drug Synergism
FMRFamide
Grasshoppers/drug effects
Intestines/physiology
Invertebrate Hormones/pharmacology
Molecular Sequence Data
Morphine/pharmacology
Muscle Contraction/drug effects
Muscle Relaxation/drug effects
Naloxone/pharmacology
Neuropeptides/pharmacology
Serotonin/pharmacology

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10.1016/0742-8413(92)90014-x

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title = "Effects of FMRFamide-related peptides and morphine on the isolated foregut of the locust Schistocerca gregaria",

abstract = "1. Morphine and YAGFMamide were the most effective potentiators of 5-hydroxytryptamine (5-HT)-induced relaxation of the isolated foregut. 2. Morphine had no effect on proctolin-induced tissue contraction which was inhibited by YGGFMamide and YFMRFamide. 3. The differing potency of FaRPs and morphine to potentiate 5-HT effects and reduce proctolin responses suggests that there are two separate FaRP receptor sub types. 4. This proposal is supported by the observation that, while naloxone (10(-5) M) is a relatively potent antagonist of FaRP induced inhibition of proctolin contraction, it has less effect on FaRP-induced potentiation of 5-HT-induced relaxation.",

keywords = "Amino Acid Sequence, Animals, Drug Synergism, FMRFamide, Grasshoppers/drug effects, Intestines/physiology, Invertebrate Hormones/pharmacology, Molecular Sequence Data, Morphine/pharmacology, Muscle Contraction/drug effects, Muscle Relaxation/drug effects, Naloxone/pharmacology, Neuropeptides/pharmacology, Serotonin/pharmacology",

author = "Wood, \{S J\} and Osborne, \{R H\} and Banner, \{S E\} and Cattell, \{K J\}",

year = "1992",

month = oct,

doi = "10.1016/0742-8413(92)90014-x",

language = "English",

volume = "103",

pages = "315--20",

journal = "Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology",

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T1 - Effects of FMRFamide-related peptides and morphine on the isolated foregut of the locust Schistocerca gregaria

AU - Wood, S J

AU - Osborne, R H

AU - Banner, S E

AU - Cattell, K J

PY - 1992/10

Y1 - 1992/10

N2 - 1. Morphine and YAGFMamide were the most effective potentiators of 5-hydroxytryptamine (5-HT)-induced relaxation of the isolated foregut. 2. Morphine had no effect on proctolin-induced tissue contraction which was inhibited by YGGFMamide and YFMRFamide. 3. The differing potency of FaRPs and morphine to potentiate 5-HT effects and reduce proctolin responses suggests that there are two separate FaRP receptor sub types. 4. This proposal is supported by the observation that, while naloxone (10(-5) M) is a relatively potent antagonist of FaRP induced inhibition of proctolin contraction, it has less effect on FaRP-induced potentiation of 5-HT-induced relaxation.

AB - 1. Morphine and YAGFMamide were the most effective potentiators of 5-hydroxytryptamine (5-HT)-induced relaxation of the isolated foregut. 2. Morphine had no effect on proctolin-induced tissue contraction which was inhibited by YGGFMamide and YFMRFamide. 3. The differing potency of FaRPs and morphine to potentiate 5-HT effects and reduce proctolin responses suggests that there are two separate FaRP receptor sub types. 4. This proposal is supported by the observation that, while naloxone (10(-5) M) is a relatively potent antagonist of FaRP induced inhibition of proctolin contraction, it has less effect on FaRP-induced potentiation of 5-HT-induced relaxation.

KW - Amino Acid Sequence

KW - Animals

KW - Drug Synergism

KW - FMRFamide

KW - Grasshoppers/drug effects

KW - Intestines/physiology

KW - Invertebrate Hormones/pharmacology

KW - Molecular Sequence Data

KW - Morphine/pharmacology

KW - Muscle Contraction/drug effects

KW - Muscle Relaxation/drug effects

KW - Naloxone/pharmacology

KW - Neuropeptides/pharmacology

KW - Serotonin/pharmacology

UR - https://www.scopus.com/pages/publications/0026496758

U2 - 10.1016/0742-8413(92)90014-x

DO - 10.1016/0742-8413(92)90014-x

M3 - Article

C2 - 1360389

SN - 0742-8413

VL - 103

SP - 315

EP - 320

JO - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology

JF - Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology

IS - 2

ER -

Effects of FMRFamide-related peptides and morphine on the isolated foregut of the locust Schistocerca gregaria

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Keywords

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