Effects of exercise mode on postprandial metabolism in humans with chronic paraplegia: Exercise and postprandial metabolism in SCI

David W McMillan, Jennifer L Maher, Kevin A Jacobs, Armando J Mendez, Mark S Nash, James L J Bilzon

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: The purpose of this study was to assess the acute effects of exercise mode and intensity on postprandial macronutrient metabolism.

METHODS: Ten healthy men age 39 ± 10 yr with chronic paraplegia (13.2 ± 8.8 yr, ASIA A-C) completed three isocaloric bouts of upper-body exercise and a resting control. After an overnight fast, participants completed circuit resistance exercise (CRE) first and the following conditions in a randomized order, separated by >48 h: i) control (CON), ~45-min seated rest; ii) moderate-intensity continuous exercise (MICE), ~40-min arm cranking at a resistance equivalent to ~30% peak power output (PPO); and iii) high-intensity interval exercise (HIIE), ~30 min arm cranking with resistance alternating every 2 min between 10% PPO and 70% PPO. After each condition, participants completed a mixed-meal tolerance test consisting of a 2510-kJ liquid meal (35% fat, 50% carbohydrate, 15% protein). Blood and expired gas samples were collected at baseline and regular intervals for 150 min after a meal.

RESULTS: An interaction (P < 0.001) was observed, with rates of lipid oxidation elevated above CON in HIIE until 60 min after a meal and in CRE at all postprandial time points up to 150 min after a meal. Postprandial blood glycerol was greater in MICE (P = 0.020) and CRE (P = 0.001) compared with CON. Furthermore, nonesterified fatty acid area under the curve had a moderate-to-strong effect in CRE versus MICE and HIIE (Cohen's d = -0.76 and -0.50, respectively).

CONCLUSIONS: In persons with paraplegia, high-intensity exercise increased postprandial energy expenditure independent of the energy cost of exercise. Furthermore, exercise combining resistance and endurance modes (CRE) showed the greater effect on postprandial lipid oxidation.

Original languageEnglish
Pages (from-to)1495-1504
Number of pages10
JournalMedicine and Science in Sports and Exercise
Volume53
Issue number7
Early online date29 Dec 2020
DOIs
Publication statusE-pub ahead of print - 29 Dec 2020

Keywords

  • Spinal cord injury
  • Interval exercise
  • circuit resistance exercise
  • Upper-body exercise
  • Exercise intensity
  • Mixed meal tolerance test

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