TY - JOUR
T1 - Effects of cannabinoids on resting state functional brain connectivity
T2 - A systematic review
AU - Lorenzetti, Valentina
AU - Gaillard, Alexandra
AU - Thomson, Diny
AU - Englund, Amir
AU - Freeman, Tom P.
N1 - Funding Information:
We thank — for her contribution to data extraction to an early draft of the manuscript. Valentina Lorenzetti was supported by an Al and val Rosentrauss Research Fellowship, by an NHMRC Investigator Fellowship and by an Australian Catholic University competitive scheme. We thank Arush Honnedevasthana Arun for reviewing of content in tables.
PY - 2023/2/28
Y1 - 2023/2/28
N2 - Cannabis products are widely used for medical and non-medical reasons worldwide and vary in content of cannabinoids such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Resting state functional connectivity offers a powerful tool to investigate the effects of cannabinoids on the human brain. We systematically reviewed functional neuroimaging evidence of connectivity during acute cannabinoid administration. A pre-registered (PROSPERO ID: CRD42020184264) systematic review of 13 studies comprising 318 participants (mean age of 25 years) was conducted and reported using the PRISMA checklist. During THC and THCv exposure vs placebo reduced connectivity with the NAcc was widely reported. Limited evidence shows that such effects are offset by co-administration of CBD. NAcc-frontal region connectivity was associated with intoxication levels. Cannabis intoxication vs placebo was associated with lower striatal-ACC connectivity. CBD and CBDv vs placebo were associated with both higher and lower connectivity between striatal-prefrontal/other regions. Overall, cannabis and cannabinoids change functional connectivity in the human brain during resting state as a function of the type of cannabinoid examined.
AB - Cannabis products are widely used for medical and non-medical reasons worldwide and vary in content of cannabinoids such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Resting state functional connectivity offers a powerful tool to investigate the effects of cannabinoids on the human brain. We systematically reviewed functional neuroimaging evidence of connectivity during acute cannabinoid administration. A pre-registered (PROSPERO ID: CRD42020184264) systematic review of 13 studies comprising 318 participants (mean age of 25 years) was conducted and reported using the PRISMA checklist. During THC and THCv exposure vs placebo reduced connectivity with the NAcc was widely reported. Limited evidence shows that such effects are offset by co-administration of CBD. NAcc-frontal region connectivity was associated with intoxication levels. Cannabis intoxication vs placebo was associated with lower striatal-ACC connectivity. CBD and CBDv vs placebo were associated with both higher and lower connectivity between striatal-prefrontal/other regions. Overall, cannabis and cannabinoids change functional connectivity in the human brain during resting state as a function of the type of cannabinoid examined.
KW - Cannabidiol (CBD)
KW - Cannabinoids
KW - Cannabis
KW - Functional magnetic resonance imaging (fMRI)
KW - Resting state functional connectivity
KW - Tetrahydrocannabinol (THC)
UR - http://www.scopus.com/inward/record.url?scp=85146004792&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2022.105014
DO - 10.1016/j.neubiorev.2022.105014
M3 - Review article
C2 - 36563921
AN - SCOPUS:85146004792
VL - 145
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
M1 - 105014
ER -