Effect of processing history on the surface interfacial properties of budesonide in carrier-based dry-powder inhalers

Jagdeep Shur, Chonladda Pitchayajittipong, Philippe Rogueda, Robert Price

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Influence of air-jet micronization, post-micronization conditioning and storage on the surface properties of budesonide in dry-powder inhaler formulations was investigated. Crystalline budesonide was air jet-micronized and conditioned using organic vapor. Particle engineering was also used to fabricate respirable particles of budesonide. Surface imaging by atomic force microscopy suggested that micronized material possessed process-induced surface disorder, which relaxed upon conditioning with organic vapor. Particle engineered material was devoid of such surface disorder. Surface interfacial properties of all batches were different and correlated to in vitro fine particle delivery. The surface properties and in vitro performance of the conditioned material changed upon storage of the budesonide at 44% relative humidity and 25°C, while the micronized and particle-engineered material remained stable. These data suggest that processing conditions of budesonide affected the surface properties of the material, which was demonstrated to have direct affect on dry-powder inhaler formulation performance.
Original languageEnglish
Pages (from-to)925-937
Number of pages13
JournalTherapeutic Delivery
Volume4
Issue number8
DOIs
Publication statusPublished - 1 Aug 2013

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