Effect of absorbed fatty acids on physical properties of ultra-high molecular weight polyethylene

Research output: Contribution to conferencePoster

Abstract

Studies have demonstrated fatty acids diffuse into ultra-high molecular weight polyethylene (UHMWPE) prosthetic components (Costa, Biomaterials, 2001), but their effect on the physical properties remains poorly understood. One of the main fatty acids present in synovial fluid is octadecadienoic acid. We compared the properties of UHMWPE tensile test samples doped with <i>cis</i>-9,<i>cis</i>-12-Octadecadienoic acid (Sigma Aldrich) for 24 h at 100 <sup>o</sup>C to control samples heated to 100 <sup>o</sup>C for 24 h in air. Both cross-sectional area and weight increased after doping (area increase: 1.3% &plusmn 0.2, weight increase: 3% &plusmn 0.28). Infrared spectroscopy (Perkin-Elmer Frontier with ATR, 32 scans, from 4000 to 600 cm<sup>-1</sup>) confirmed the presence of octadecadienoic acid (peak at 309 cm<sup>-1</sup>). Differential scanning calorimetry results showed doping significantly decreased the crystallinity (p=0.015, n=3) and the melting temperature (p=0.001, n=3). Tensile tests (n=5) were carried out in accordance with ISO527 using an electromechanical testing machine (Instron 5965) and a contact extensometer, at a rate of 50 mm/min. The doped samples had significantly lower yield stress (p&lt0.0001) and elongation at failure (p=0.03), but no change was found in modulus or ultimate stress. The results demonstrate the absorption of octadecadienoic acid, which happens over time <i>in vivo</i>, alters UHMWPE dimensions, reduces crystallinity, melting temperature, yield stress, and elongation at failure. Consequently, it is important that the effect of fatty acid absorption is taken into account when performing <i>in vitro</i> tests of UHMWPE components, such as wear testing. The dimensional change also has implications for close fitting component designs.

Conference

ConferenceBritish Orthopaedic Research Society Annual Meeting
CountryUK United Kingdom
CityLondon
Period4/09/175/09/17

Fingerprint

fatty acid
physical property
acid
crystallinity
melting
calorimetry
infrared spectroscopy
effect
temperature
fluid
air
test

Keywords

  • orthopaedic
  • polyethylene

Cite this

Hossein Zadeh Zaribaf, P., Gill, H., & Pegg, E. (2017). Effect of absorbed fatty acids on physical properties of ultra-high molecular weight polyethylene. Poster session presented at British Orthopaedic Research Society Annual Meeting, London, UK United Kingdom.

Effect of absorbed fatty acids on physical properties of ultra-high molecular weight polyethylene. / Hossein Zadeh Zaribaf, Parnian; Gill, Harinderjit; Pegg, Elise.

2017. Poster session presented at British Orthopaedic Research Society Annual Meeting, London, UK United Kingdom.

Research output: Contribution to conferencePoster

Hossein Zadeh Zaribaf, P, Gill, H & Pegg, E 2017, 'Effect of absorbed fatty acids on physical properties of ultra-high molecular weight polyethylene' British Orthopaedic Research Society Annual Meeting, London, UK United Kingdom, 4/09/17 - 5/09/17, .
Hossein Zadeh Zaribaf P, Gill H, Pegg E. Effect of absorbed fatty acids on physical properties of ultra-high molecular weight polyethylene. 2017. Poster session presented at British Orthopaedic Research Society Annual Meeting, London, UK United Kingdom.
Hossein Zadeh Zaribaf, Parnian ; Gill, Harinderjit ; Pegg, Elise. / Effect of absorbed fatty acids on physical properties of ultra-high molecular weight polyethylene. Poster session presented at British Orthopaedic Research Society Annual Meeting, London, UK United Kingdom.
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abstract = "Studies have demonstrated fatty acids diffuse into ultra-high molecular weight polyethylene (UHMWPE) prosthetic components (Costa, Biomaterials, 2001), but their effect on the physical properties remains poorly understood. One of the main fatty acids present in synovial fluid is octadecadienoic acid. We compared the properties of UHMWPE tensile test samples doped with cis-9,cis-12-Octadecadienoic acid (Sigma Aldrich) for 24 h at 100 oC to control samples heated to 100 oC for 24 h in air. Both cross-sectional area and weight increased after doping (area increase: 1.3{\%} &plusmn 0.2, weight increase: 3{\%} &plusmn 0.28). Infrared spectroscopy (Perkin-Elmer Frontier with ATR, 32 scans, from 4000 to 600 cm-1) confirmed the presence of octadecadienoic acid (peak at 309 cm-1). Differential scanning calorimetry results showed doping significantly decreased the crystallinity (p=0.015, n=3) and the melting temperature (p=0.001, n=3). Tensile tests (n=5) were carried out in accordance with ISO527 using an electromechanical testing machine (Instron 5965) and a contact extensometer, at a rate of 50 mm/min. The doped samples had significantly lower yield stress (p&lt0.0001) and elongation at failure (p=0.03), but no change was found in modulus or ultimate stress. The results demonstrate the absorption of octadecadienoic acid, which happens over time in vivo, alters UHMWPE dimensions, reduces crystallinity, melting temperature, yield stress, and elongation at failure. Consequently, it is important that the effect of fatty acid absorption is taken into account when performing in vitro tests of UHMWPE components, such as wear testing. The dimensional change also has implications for close fitting component designs.",
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N2 - Studies have demonstrated fatty acids diffuse into ultra-high molecular weight polyethylene (UHMWPE) prosthetic components (Costa, Biomaterials, 2001), but their effect on the physical properties remains poorly understood. One of the main fatty acids present in synovial fluid is octadecadienoic acid. We compared the properties of UHMWPE tensile test samples doped with cis-9,cis-12-Octadecadienoic acid (Sigma Aldrich) for 24 h at 100 oC to control samples heated to 100 oC for 24 h in air. Both cross-sectional area and weight increased after doping (area increase: 1.3% &plusmn 0.2, weight increase: 3% &plusmn 0.28). Infrared spectroscopy (Perkin-Elmer Frontier with ATR, 32 scans, from 4000 to 600 cm-1) confirmed the presence of octadecadienoic acid (peak at 309 cm-1). Differential scanning calorimetry results showed doping significantly decreased the crystallinity (p=0.015, n=3) and the melting temperature (p=0.001, n=3). Tensile tests (n=5) were carried out in accordance with ISO527 using an electromechanical testing machine (Instron 5965) and a contact extensometer, at a rate of 50 mm/min. The doped samples had significantly lower yield stress (p&lt0.0001) and elongation at failure (p=0.03), but no change was found in modulus or ultimate stress. The results demonstrate the absorption of octadecadienoic acid, which happens over time in vivo, alters UHMWPE dimensions, reduces crystallinity, melting temperature, yield stress, and elongation at failure. Consequently, it is important that the effect of fatty acid absorption is taken into account when performing in vitro tests of UHMWPE components, such as wear testing. The dimensional change also has implications for close fitting component designs.

AB - Studies have demonstrated fatty acids diffuse into ultra-high molecular weight polyethylene (UHMWPE) prosthetic components (Costa, Biomaterials, 2001), but their effect on the physical properties remains poorly understood. One of the main fatty acids present in synovial fluid is octadecadienoic acid. We compared the properties of UHMWPE tensile test samples doped with cis-9,cis-12-Octadecadienoic acid (Sigma Aldrich) for 24 h at 100 oC to control samples heated to 100 oC for 24 h in air. Both cross-sectional area and weight increased after doping (area increase: 1.3% &plusmn 0.2, weight increase: 3% &plusmn 0.28). Infrared spectroscopy (Perkin-Elmer Frontier with ATR, 32 scans, from 4000 to 600 cm-1) confirmed the presence of octadecadienoic acid (peak at 309 cm-1). Differential scanning calorimetry results showed doping significantly decreased the crystallinity (p=0.015, n=3) and the melting temperature (p=0.001, n=3). Tensile tests (n=5) were carried out in accordance with ISO527 using an electromechanical testing machine (Instron 5965) and a contact extensometer, at a rate of 50 mm/min. The doped samples had significantly lower yield stress (p&lt0.0001) and elongation at failure (p=0.03), but no change was found in modulus or ultimate stress. The results demonstrate the absorption of octadecadienoic acid, which happens over time in vivo, alters UHMWPE dimensions, reduces crystallinity, melting temperature, yield stress, and elongation at failure. Consequently, it is important that the effect of fatty acid absorption is taken into account when performing in vitro tests of UHMWPE components, such as wear testing. The dimensional change also has implications for close fitting component designs.

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KW - polyethylene

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