Eccentric exercise as an adjuvant to hepatitis B and meningitis ACWY vaccinations

J. E. Long, J. Campbell, V. Burns, J. Bosch, M. Drayson, C. Ring, K. Edwards

Research output: Contribution to journalMeeting abstract

Abstract

It has been speculated that eccentric exercise improves antibody responses to vaccines by inducing a pro-inflammatory environment at the site of administration. However, eccentric exercise also induces immunological changes at a systemic level. This study investigated whether exercise-induced changes in the antibody response are mediated locally or systemically. Seventy eight participants completed eccentric arm exercise (n = 59) or rested (n = 19), before receiving hepatitis B and meningitis ACWY vaccines into opposite arms. Thirty-one exercise participants received the hepatitis B vaccine into the exercised arm; 28 received the opposite configuration. IgG against hepatitis B and meningitis ACWY were assessed at baseline and 28 days. IgM against hepatitis B was assessed at baseline and 7 days. Repeated measures ANOVA compared exercise groups to control, and then each exercise group to each other. Sex was entered as a between-subject factor. There was a trend towards exercise augmenting the IgM response to hepatitis B in women (Time × Group × Sex interaction; p = .07); no difference was found between the exercise groups. There were no effects of exercise on the IgG response to hepatitis B or any of the meningitis strains, compared to control. Eccentric exercise has a limited adjuvant effect on the efficacy of hepatitis B and meningitis ACWY vaccinations. Future studies should readdress whether immune augmentation is mediated via local or systemic mechanisms using influenza vaccine.
LanguageEnglish
PagesS33
Number of pages1
JournalBrain Behavior and Immunity
Volume24
Issue number1
DOIs
StatusPublished - 1 Aug 2010

Fingerprint

Hepatitis B
Meningitis
Vaccination
Exercise
Antibody Formation
Immunoglobulin M
Vaccines
Immunoglobulin G
Hepatitis B Vaccines
Influenza Vaccines
Analysis of Variance
Control Groups

Keywords

  • adjuvant
  • immunoglobulin G
  • immunoglobulin M
  • vaccine
  • hepatitis B vaccine
  • influenza vaccine
  • exercise
  • vaccination
  • meningitis
  • hepatitis B
  • psychophysiology
  • society
  • arm
  • antibody response
  • arm exercise
  • female
  • adjuvant therapy
  • environment
  • analysis of variance

Cite this

Eccentric exercise as an adjuvant to hepatitis B and meningitis ACWY vaccinations. / Long, J. E.; Campbell, J.; Burns, V.; Bosch, J.; Drayson, M.; Ring, C.; Edwards, K.

In: Brain Behavior and Immunity, Vol. 24, No. 1, 01.08.2010, p. S33.

Research output: Contribution to journalMeeting abstract

Long, J. E. ; Campbell, J. ; Burns, V. ; Bosch, J. ; Drayson, M. ; Ring, C. ; Edwards, K. / Eccentric exercise as an adjuvant to hepatitis B and meningitis ACWY vaccinations. In: Brain Behavior and Immunity. 2010 ; Vol. 24, No. 1. pp. S33.
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