E069 The efficacy of dietary intervention on gastrointestinal involvement in systemic sclerosis: a systematic literature review

Background: Gastrointestinal involvement in systemic sclerosis is common and a major cause of disease-related morbidity. Patients regularly enquire about dietary modifications that may help with gastrointestinal symptoms of SSc. Many clinical practice reviews and treatment guidelines make specific reference to dietary modifications in the management of gastrointestinal involvement in systemic sclerosis. We report the findings of a systematic literature review designed to evaluate the evidence to support dietary modification in the management of gastrointestinal symptoms of systemic sclerosis.Methods: A systematic literature review protocol was developed according to Preferred Reporting Items for systematic reviews and meta-analyses guidelines and registered with the international prospective register of systematic reviews (CRD42018103549). Standardised searches of EMBASE and MEDLINE were undertaken to identify studies reporting the outcome of dietary modification in the management of gastrointestinal symptoms of systemic sclerosis. Wide heterogeneity in study design, interventions and study outcomes necessitated a qualitative data synthesis.