Projects per year
Abstract
To understand the mechanism of biological processes, time-resolved methodologies are required to investigate how functionality is linked to changes in molecular structure. A number of spectroscopic techniques are available that probe local structural rearrangements with high temporal resolution. However, for macromolecules, these techniques do not yield an overall high-resolution description of the structure. Time-resolved X-ray crystallographic methods exist, but, due to both instrument availability and stringent sample requirements, they have not been widely applied to macromolecular systems, especially for time resolutions below 1 s. Recently, there has been a resurgent interest in time-resolved structural science, fuelled by the recognition that both chemical and life scientists face many of the same challenges. In the present article, we review the current state-of-the-art in dynamic structural science, highlighting applications to enzymes. We also look to the future and discuss current method developments with the potential to widen access to time-resolved studies across discipline boundaries
Original language | English |
---|---|
Pages (from-to) | 1260-1264 |
Number of pages | 5 |
Journal | Biochemical Society Transactions |
Volume | 41 |
Issue number | 5 |
DOIs | |
Publication status | Published - Oct 2013 |
Fingerprint
Dive into the research topics of 'Dynamic structural science: Recent developments in time-resolved spectroscopy and X-ray crystallography'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Dynamic Structural Science at the RC@H
Raithby, P. (PI)
Engineering and Physical Sciences Research Council
1/03/11 → 31/08/16
Project: Research council