Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections

T.M. Postma; W.R.J.D. Galloway; F.B.L. Cougnon; G. Dan Pantos; J.E. Stokes; D.R. Spring

doi:10.1055/s-0032-1318407

Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections

T.M. Postma, W.R.J.D. Galloway, F.B.L. Cougnon, G. Dan Pantos, J.E. Stokes, D.R. Spring

University of Cambridge

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

Abstract

We describe the synthesis of a range of novel dithiol-functionalized building blocks and demonstrate how they can be used to generate new structurally diverse dynamic combinatorial libraries. A proof-of-principle experiment using the catecholamine dopamine revealed that molecular recognition changed the library composition under biocompatible conditions and identified new promising candidate receptors of this biologically important neurotransmitter.

Original language	English
Pages (from-to)	765-769
Number of pages	5
Journal	Synlett
Volume	24
Issue number	6
DOIs	https://doi.org/10.1055/s-0032-1318407
Publication status	Published - 2013

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Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections

Abstract

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