Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections

T.M. Postma, W.R.J.D. Galloway, F.B.L. Cougnon, G. Dan Pantos, J.E. Stokes, D.R. Spring

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We describe the synthesis of a range of novel dithiol-functionalized building blocks and demonstrate how they can be used to generate new structurally diverse dynamic combinatorial libraries. A proof-of-principle experiment using the catecholamine dopamine revealed that molecular recognition changed the library composition under biocompatible conditions and identified new promising candidate receptors of this biologically important neurotransmitter.
Original languageEnglish
Pages (from-to)765-769
Number of pages5
JournalSynlett
Volume24
Issue number6
DOIs
Publication statusPublished - 2013

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