Oil-in-water microcapsules with varying shell thicknesses were fabricated via a coacervation technique, whereby evaporation of volatile solvents induced the shell-forming polymer to precipitate, phase separate and migrate to the oil/water interface to form microcapsules. These microcapsules encapsulated a lipophilic dye within their cores and were applied topically onto porcine skin for 6 h. Results indicated that the dye preferentially accumulated within the skin furrows and hair follicles, though the dye did not penetrate beyond the stratum corneum. A model estimates the diffusion coefficients of dye through the microcapsule shell and within the skin to be approximately 10(-18) and 10(-16) m(2) s(-1), respectively.
|Number of pages||7|
|Journal||European Journal of Pharmaceutics and Biopharmaceutics|
|Publication status||Published - 2009|
- Skin diffusion
Yow, H. N., Wu, X., Routh, A. F., & Guy, R. H. (2009). Dye diffusion from microcapsules with different shell thickness into mammalian skin. European Journal of Pharmaceutics and Biopharmaceutics, 72(1), 62-68. https://doi.org/10.1016/j.ejpb.2008.11.004