Dye diffusion from microcapsules with different shell thickness into mammalian skin

H N Yow, Xiao Wu, A F Routh, Richard H Guy

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Oil-in-water microcapsules with varying shell thicknesses were fabricated via a coacervation technique, whereby evaporation of volatile solvents induced the shell-forming polymer to precipitate, phase separate and migrate to the oil/water interface to form microcapsules. These microcapsules encapsulated a lipophilic dye within their cores and were applied topically onto porcine skin for 6 h. Results indicated that the dye preferentially accumulated within the skin furrows and hair follicles, though the dye did not penetrate beyond the stratum corneum. A model estimates the diffusion coefficients of dye through the microcapsule shell and within the skin to be approximately 10(-18) and 10(-16) m(2) s(-1), respectively.
Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume72
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Skin diffusion
  • Microcapsules
  • Encapsulation

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