Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression

Linda K. Rushworth; Andrew M. Kidger; Laurent Delavaine; Graeme Stewart; Susanne Van Schelven; Jane Davidson; Christopher J. Bryant; Edward Caddye; Philip East; Christopher J. Caunt; Stephen M. Keyse

doi:10.1073/pnas.1420159112

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression

Linda K. Rushworth
, Andrew M. Kidger
, Laurent Delavaine
, Graeme Stewart
, Susanne Van Schelven
, Jane Davidson
, Christopher J. Bryant
, Edward Caddye
, Philip East
, Christopher J. Caunt
, Stephen M. Keyse

Department of Life Sciences

University of Dundee
Cancer Research UK

Research output: Contribution to journal › Article › peer-review

69 Citations (SciVal)

Original language	English
Pages (from-to)	18267-18272
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	111
Issue number	51
Early online date	8 Dec 2014
DOIs	https://doi.org/10.1073/pnas.1420159112
Publication status	Published - 23 Dec 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

DUSP5
MAP Kinase
Protein phosphatases
SerpinB2
Skin cancer

Access to Document

10.1073/pnas.1420159112

Cite this

Rushworth, L. K., Kidger, A. M., Delavaine, L., Stewart, G., Van Schelven, S., Davidson, J., Bryant, C. J., Caddye, E., East, P., Caunt, C. J., & Keyse, S. M. (2014). Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. Proceedings of the National Academy of Sciences of the United States of America, 111(51), 18267-18272. https://doi.org/10.1073/pnas.1420159112

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. / Rushworth, Linda K.; Kidger, Andrew M.; Delavaine, Laurent et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 51, 23.12.2014, p. 18267-18272.

Research output: Contribution to journal › Article › peer-review

Rushworth, LK, Kidger, AM, Delavaine, L, Stewart, G, Van Schelven, S, Davidson, J, Bryant, CJ, Caddye, E, East, P, Caunt, CJ & Keyse, SM 2014, 'Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 51, pp. 18267-18272. https://doi.org/10.1073/pnas.1420159112

Rushworth LK, Kidger AM, Delavaine L, Stewart G, Van Schelven S, Davidson J et al. Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec 23;111(51):18267-18272. Epub 2014 Dec 8. doi: 10.1073/pnas.1420159112

@article{5761f5b9bbfa46e0957ec9aecc2f518f,

title = "Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression",

keywords = "DUSP5, MAP Kinase, Protein phosphatases, SerpinB2, Skin cancer",

author = "Rushworth, \{Linda K.\} and Kidger, \{Andrew M.\} and Laurent Delavaine and Graeme Stewart and \{Van Schelven\}, Susanne and Jane Davidson and Bryant, \{Christopher J.\} and Edward Caddye and Philip East and Caunt, \{Christopher J.\} and Keyse, \{Stephen M.\}",

year = "2014",

month = dec,

day = "23",

doi = "10.1073/pnas.1420159112",

language = "English",

volume = "111",

pages = "18267--18272",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "51",

}

TY - JOUR

T1 - Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression

AU - Rushworth, Linda K.

AU - Kidger, Andrew M.

AU - Delavaine, Laurent

AU - Stewart, Graeme

AU - Van Schelven, Susanne

AU - Davidson, Jane

AU - Bryant, Christopher J.

AU - Caddye, Edward

AU - East, Philip

AU - Caunt, Christopher J.

AU - Keyse, Stephen M.

PY - 2014/12/23

Y1 - 2014/12/23

KW - DUSP5

KW - MAP Kinase

KW - Protein phosphatases

KW - SerpinB2

KW - Skin cancer

U2 - 10.1073/pnas.1420159112

DO - 10.1073/pnas.1420159112

M3 - Article

SN - 0027-8424

VL - 111

SP - 18267

EP - 18272

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 51

ER -