Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression

Linda K. Rushworth; Andrew M. Kidger; Laurent Delavaine; Graeme Stewart; Susanne Van Schelven; Jane Davidson; Christopher J. Bryant; Edward Caddye; Philip East; Christopher J. Caunt; Stephen M. Keyse

doi:10.1073/pnas.1420159112

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression

Linda K. Rushworth, Andrew M. Kidger, Laurent Delavaine, Graeme Stewart, Susanne Van Schelven, Jane Davidson, Christopher J. Bryant, Edward Caddye, Philip East, Christopher J. Caunt, Stephen M. Keyse

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

63 Citations (SciVal)

Original language	English
Pages (from-to)	18267-18272
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	111
Issue number	51
Early online date	8 Dec 2014
DOIs	https://doi.org/10.1073/pnas.1420159112
Publication status	Published - 23 Dec 2014

Keywords

DUSP5
MAP Kinase
Protein phosphatases
SerpinB2
Skin cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1073/pnas.1420159112

Cite this

Rushworth, L. K., Kidger, A. M., Delavaine, L., Stewart, G., Van Schelven, S., Davidson, J., Bryant, C. J., Caddye, E., East, P., Caunt, C. J., & Keyse, S. M. (2014). Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. Proceedings of the National Academy of Sciences of the United States of America, 111(51), 18267-18272. https://doi.org/10.1073/pnas.1420159112

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. / Rushworth, Linda K.; Kidger, Andrew M.; Delavaine, Laurent et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 51, 23.12.2014, p. 18267-18272.

Research output: Contribution to journal › Article › peer-review

Rushworth, LK, Kidger, AM, Delavaine, L, Stewart, G, Van Schelven, S, Davidson, J, Bryant, CJ, Caddye, E, East, P, Caunt, CJ & Keyse, SM 2014, 'Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 51, pp. 18267-18272. https://doi.org/10.1073/pnas.1420159112

Rushworth LK, Kidger AM, Delavaine L, Stewart G, Van Schelven S, Davidson J et al. Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec 23;111(51):18267-18272. Epub 2014 Dec 8. doi: 10.1073/pnas.1420159112

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AU - Davidson, Jane

AU - Bryant, Christopher J.

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