Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression

Linda K. Rushworth, Andrew M. Kidger, Laurent Delavaine, Graeme Stewart, Susanne Van Schelven, Jane Davidson, Christopher J. Bryant, Edward Caddye, Philip East, Christopher J. Caunt, Stephen M. Keyse

Research output: Contribution to journalArticle

35 Citations (Scopus)
Original languageEnglish
Pages (from-to)18267-18272
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number51
Early online date8 Dec 2014
DOIs
Publication statusPublished - 23 Dec 2014

Keywords

  • DUSP5
  • MAP Kinase
  • Protein phosphatases
  • SerpinB2
  • Skin cancer

Cite this

Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. / Rushworth, Linda K.; Kidger, Andrew M.; Delavaine, Laurent; Stewart, Graeme; Van Schelven, Susanne; Davidson, Jane; Bryant, Christopher J.; Caddye, Edward; East, Philip; Caunt, Christopher J.; Keyse, Stephen M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 51, 23.12.2014, p. 18267-18272.

Research output: Contribution to journalArticle

Rushworth, Linda K. ; Kidger, Andrew M. ; Delavaine, Laurent ; Stewart, Graeme ; Van Schelven, Susanne ; Davidson, Jane ; Bryant, Christopher J. ; Caddye, Edward ; East, Philip ; Caunt, Christopher J. ; Keyse, Stephen M. / Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. In: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Vol. 111, No. 51. pp. 18267-18272.
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AU - Stewart, Graeme

AU - Van Schelven, Susanne

AU - Davidson, Jane

AU - Bryant, Christopher J.

AU - Caddye, Edward

AU - East, Philip

AU - Caunt, Christopher J.

AU - Keyse, Stephen M.

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