Dual selective iron chelating probes for the monitoring of mitochondrial labile iron pools

Vincenzo Abbate; Olivier Reelfs; Xiaole Kong; Charareh Pourzand; Robert C Hider

doi:10.1039/C5CC06170A

Dual selective iron chelating probes for the monitoring of mitochondrial labile iron pools

Vincenzo Abbate, Olivier Reelfs, Xiaole Kong, Charareh Pourzand, Robert C Hider

Department of Life Sciences

King's College London

Research output: Contribution to journal › Article › peer-review

24 Citations (SciVal)

62 Downloads (Pure)

Abstract

Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

Original language	English
Pages (from-to)	784-787
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	4
Early online date	9 Nov 2015
DOIs	https://doi.org/10.1039/C5CC06170A
Publication status	Published - 14 Jan 2016

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10.1039/C5CC06170A

C5CC06170AAccepted author manuscript, 735 KB

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title = "Dual selective iron chelating probes for the monitoring of mitochondrial labile iron pools",

abstract = "Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.",

author = "Vincenzo Abbate and Olivier Reelfs and Xiaole Kong and Charareh Pourzand and Hider, {Robert C}",

year = "2016",

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T1 - Dual selective iron chelating probes for the monitoring of mitochondrial labile iron pools

AU - Abbate, Vincenzo

AU - Reelfs, Olivier

AU - Kong, Xiaole

AU - Pourzand, Charareh

AU - Hider, Robert C

PY - 2016/1/14

Y1 - 2016/1/14

N2 - Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

AB - Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.

UR - http://dx.doi.org/10.1039/C5CC06170A

U2 - 10.1039/C5CC06170A

DO - 10.1039/C5CC06170A

M3 - Article

SN - 1359-7345

VL - 52

SP - 784

EP - 787

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

Dual selective iron chelating probes for the monitoring of mitochondrial labile iron pools

Abstract

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Mitochondrial and Lysosomal-Targeted Iron Chelators for the Monitoring and Adjustment of Cellular Labile Iron Pools

Charareh Pourzand

MC2-Bioimaging and cell analysis

MC2-Mass Spectrometry (MS)

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Dual selective iron chelating probes for the monitoring of mitochondrial labile iron pools

Abstract

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Projects

Mitochondrial and Lysosomal-Targeted Iron Chelators for the Monitoring and Adjustment of Cellular Labile Iron Pools

Profiles

Charareh Pourzand

Equipment

MC2-Bioimaging and cell analysis

MC2-Mass Spectrometry (MS)

Cite this