Dual Mechanism for the Emergence of Synchronization in Inhibitory Neural Networks

Ashok Chauhan, Joseph Taylor, Alain Nogaret

Research output: Contribution to journal › Article

2 Citations (Scopus)
23 Downloads (Pure)

Abstract

During cognitive tasks cortical microcircuits synchronize to bind stimuli into unified perception. The emergence of coherent rhythmic activity is thought to be inhibition-driven and stimulation-dependent. However, the exact mechanisms of synchronization remain unknown. Recent optogenetic experiments have identified two neuron sub-types as the likely inhibitory vectors of synchronization. Here, we show that \textcolor{blue}{local networks mimicking the soma-targeting properties observed in fast-spiking interneurons and the dendrite-projecting properties observed in somatostatin interneurons} synchronize through different mechanisms which may provide adaptive advantages by combining flexibility and robustness. We probed the synchronization phase diagrams of small all-to-all inhibitory networks \textit{in-silico} as a function of inhibition delay, neurotransmitter kinetics, timings and intensity of stimulation. Inhibition delay is found to induce coherent oscillations over a broader range of experimental conditions than high-frequency entrainment. Inhibition delay boosts network capacity (ln2)^{-N}-fold by stabilizing locally coherent oscillations. This work may inform novel therapeutic strategies for moderating pathological cortical oscillations.
Original languageEnglish
Article number11431
Pages (from-to)1-9
Number of pages9
JournalScientific Reports
Volume8
Issue number1
Early online date30 Jul 2018
DOIs
Publication statusPublished - 1 Dec 2018

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Interneurons
Optogenetics
Carisoprodol
Dendrites
Somatostatin
Computer Simulation
Neurotransmitter Agents
Neurons
Inhibition (Psychology)
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Dual Mechanism for the Emergence of Synchronization in Inhibitory Neural Networks. / Chauhan, Ashok; Taylor, Joseph; Nogaret, Alain.

In: Scientific Reports, Vol. 8, No. 1, 11431, 01.12.2018, p. 1-9.

Research output: Contribution to journal › Article

Chauhan, A, Taylor, J & Nogaret, A 2018, 'Dual Mechanism for the Emergence of Synchronization in Inhibitory Neural Networks', Scientific Reports, vol. 8, no. 1, 11431, pp. 1-9. https://doi.org/10.1038/s41598-018-29822-8
Chauhan A, Taylor J, Nogaret A. Dual Mechanism for the Emergence of Synchronization in Inhibitory Neural Networks. Scientific Reports. 2018 Dec 1;8(1):1-9. 11431. https://doi.org/10.1038/s41598-018-29822-8
Chauhan, Ashok ; Taylor, Joseph ; Nogaret, Alain. / Dual Mechanism for the Emergence of Synchronization in Inhibitory Neural Networks. In: Scientific Reports. 2018 ; Vol. 8, No. 1. pp. 1-9.
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