Abstract
| Original language | English |
|---|---|
| Article number | 11431 |
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Scientific Reports |
| Volume | 8 |
| Issue number | 1 |
| Early online date | 30 Jul 2018 |
| DOIs | |
| Publication status | Published - 1 Dec 2018 |
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Dual Mechanism for the Emergence of Synchronization in Inhibitory Neural Networks. / Chauhan, Ashok; Taylor, Joseph; Nogaret, Alain.
In: Scientific Reports, Vol. 8, No. 1, 11431, 01.12.2018, p. 1-9.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Dual Mechanism for the Emergence of Synchronization in Inhibitory Neural Networks
AU - Chauhan, Ashok
AU - Taylor, Joseph
AU - Nogaret, Alain
N1 - Manuscript SREP-17-53678B
PY - 2018/12/1
Y1 - 2018/12/1
N2 - During cognitive tasks cortical microcircuits synchronize to bind stimuli into unified perception. The emergence of coherent rhythmic activity is thought to be inhibition-driven and stimulation-dependent. However, the exact mechanisms of synchronization remain unknown. Recent optogenetic experiments have identified two neuron sub-types as the likely inhibitory vectors of synchronization. Here, we show that \textcolor{blue}{local networks mimicking the soma-targeting properties observed in fast-spiking interneurons and the dendrite-projecting properties observed in somatostatin interneurons} synchronize through different mechanisms which may provide adaptive advantages by combining flexibility and robustness. We probed the synchronization phase diagrams of small all-to-all inhibitory networks \textit{in-silico} as a function of inhibition delay, neurotransmitter kinetics, timings and intensity of stimulation. Inhibition delay is found to induce coherent oscillations over a broader range of experimental conditions than high-frequency entrainment. Inhibition delay boosts network capacity (ln2)^{-N}-fold by stabilizing locally coherent oscillations. This work may inform novel therapeutic strategies for moderating pathological cortical oscillations.
AB - During cognitive tasks cortical microcircuits synchronize to bind stimuli into unified perception. The emergence of coherent rhythmic activity is thought to be inhibition-driven and stimulation-dependent. However, the exact mechanisms of synchronization remain unknown. Recent optogenetic experiments have identified two neuron sub-types as the likely inhibitory vectors of synchronization. Here, we show that \textcolor{blue}{local networks mimicking the soma-targeting properties observed in fast-spiking interneurons and the dendrite-projecting properties observed in somatostatin interneurons} synchronize through different mechanisms which may provide adaptive advantages by combining flexibility and robustness. We probed the synchronization phase diagrams of small all-to-all inhibitory networks \textit{in-silico} as a function of inhibition delay, neurotransmitter kinetics, timings and intensity of stimulation. Inhibition delay is found to induce coherent oscillations over a broader range of experimental conditions than high-frequency entrainment. Inhibition delay boosts network capacity (ln2)^{-N}-fold by stabilizing locally coherent oscillations. This work may inform novel therapeutic strategies for moderating pathological cortical oscillations.
UR - http://www.scopus.com/inward/record.url?scp=85050802930&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-29822-8
DO - 10.1038/s41598-018-29822-8
M3 - Article
VL - 8
SP - 1
EP - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 11431
ER -