Abstract
During cognitive tasks cortical microcircuits synchronize to bind stimuli into unified perception. The emergence of coherent rhythmic activity is thought to be inhibition-driven and stimulation-dependent. However, the exact mechanisms of synchronization remain unknown. Recent optogenetic experiments have identified two neuron sub-types as the likely inhibitory vectors of synchronization. Here, we show that \textcolor{blue}{local networks mimicking the soma-targeting properties observed in fast-spiking interneurons and the dendrite-projecting properties observed in somatostatin interneurons} synchronize through different mechanisms which may provide adaptive advantages by combining flexibility and robustness. We probed the synchronization phase diagrams of small all-to-all inhibitory networks \textit{in-silico} as a function of inhibition delay, neurotransmitter kinetics, timings and intensity of stimulation. Inhibition delay is found to induce coherent oscillations over a broader range of experimental conditions than high-frequency entrainment. Inhibition delay boosts network capacity (ln2)^{-N}-fold by stabilizing locally coherent oscillations. This work may inform novel therapeutic strategies for moderating pathological cortical oscillations.
Original language | English |
---|---|
Article number | 11431 |
Pages (from-to) | 1-9 |
Number of pages | 9 |
Journal | Scientific Reports |
Volume | 8 |
Issue number | 1 |
Early online date | 30 Jul 2018 |
DOIs | |
Publication status | Published - 1 Dec 2018 |
ASJC Scopus subject areas
- General