Drugging Hedgehog: signaling the pathway to translation

Tom J Carney; Philip W Ingham

doi:10.1186/1741-7007-11-37

Drugging Hedgehog: signaling the pathway to translation

Tom J Carney, Philip W Ingham

Department of Life Sciences

Institute of Molecular and Cell Biology (IMCB)

Research output: Contribution to journal › Review article › peer-review

16 Citations (SciVal)

Abstract

First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.

Original language	English
Pages (from-to)	37
Journal	BMC Biology
Volume	11
DOIs	https://doi.org/10.1186/1741-7007-11-37
Publication status	Published - 15 Apr 2013

Keywords

Animals
Antineoplastic Agents/pharmacology
Hedgehog Proteins/antagonists & inhibitors
Humans
Signal Transduction/drug effects
Small Molecule Libraries/pharmacology
Translational Research, Biomedical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1741-7007-11-37

Cite this

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title = "Drugging Hedgehog: signaling the pathway to translation",

abstract = "First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.",

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AU - Carney, Tom J

AU - Ingham, Philip W

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N2 - First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.

AB - First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic applications. Small molecule pathway agonists are now used to program stem cells, whilst antagonists are proving effective as anti-cancer therapies.

KW - Animals

KW - Antineoplastic Agents/pharmacology

KW - Hedgehog Proteins/antagonists & inhibitors

KW - Humans

KW - Signal Transduction/drug effects

KW - Small Molecule Libraries/pharmacology

KW - Translational Research, Biomedical

U2 - 10.1186/1741-7007-11-37

DO - 10.1186/1741-7007-11-37

M3 - Review article

C2 - 23587183

SN - 1741-7007

VL - 11

SP - 37

JO - BMC Biology

JF - BMC Biology

ER -

Drugging Hedgehog: signaling the pathway to translation

Abstract

Keywords

UN SDGs

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