TY - JOUR
T1 - Drug resistance in veterinary helminths
AU - Wolstenholme, A J
AU - Fairweather, I
AU - Prichard, R
AU - von Samson-Himmelstjerna, G
AU - Sangster, N C
N1 - ID number: ISI:000224257600004
PY - 2004
Y1 - 2004
N2 - At present, there is no effective alternative to chemical control of parasitic helminths where livestock are grazed intensively. Resistance to anthelmintics has become a major problem in veterinary medicine, and threatens both agricultural income and animal welfare. The molecular and biochemical basis of this resistance is not well understood. The lack of reliable biological and molecular tests means that we are not able to follow the emergence and spread of resistance alleles and clinical resistance as well as we need. This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area.
AB - At present, there is no effective alternative to chemical control of parasitic helminths where livestock are grazed intensively. Resistance to anthelmintics has become a major problem in veterinary medicine, and threatens both agricultural income and animal welfare. The molecular and biochemical basis of this resistance is not well understood. The lack of reliable biological and molecular tests means that we are not able to follow the emergence and spread of resistance alleles and clinical resistance as well as we need. This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area.
U2 - 10.1016/j.pt.2004.07.010
DO - 10.1016/j.pt.2004.07.010
M3 - Article
SN - 1471-4922
VL - 20
SP - 469
EP - 476
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 10
ER -