Drug delivery into microneedle-porated nails from nanoparticle reservoirs

Wing Sin Chiu, Natalie A. Belsey, Natalie L. Garrett, Julian Moger, Gareth J. Price, M. Begoña Delgado-Charro, Richard H. Guy

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Abstract

This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of a fluorescent model compound from nanoparticles into the nail. A label-free imaging technique, stimulated Raman scattering microscopy, was applied, in conjunction with two-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophilic 'active' in a microneedle-porated nail. The results provide clear evidence that the nanoparticles function as immobile reservoirs, sequestered on the nail surface and in the microneedle-generated pores, from which the active payload can be released and diffuse laterally into the nail over an extended period of time.

Original languageEnglish
Pages (from-to)98-106
Number of pages9
JournalJournal of Controlled Release
Volume220
Issue numberA
Early online date23 Oct 2015
DOIs
Publication statusPublished - 28 Dec 2015

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Keywords

  • Drug delivery
  • Microneedle poration
  • Nail
  • Nanoparticles
  • Stimulated Raman scattering

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