Abstract
This study demonstrates the potential of polymeric nanoparticles as drug reservoirs for sustained topical drug delivery into microneedle-treated human nail. Laser scanning confocal microscopy was used to image the delivery of a fluorescent model compound from nanoparticles into the nail. A label-free imaging technique, stimulated Raman scattering microscopy, was applied, in conjunction with two-photon fluorescence imaging, to probe the disposition of nanoparticles and an associated lipophilic 'active' in a microneedle-porated nail. The results provide clear evidence that the nanoparticles function as immobile reservoirs, sequestered on the nail surface and in the microneedle-generated pores, from which the active payload can be released and diffuse laterally into the nail over an extended period of time.
Original language | English |
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Pages (from-to) | 98-106 |
Number of pages | 9 |
Journal | Journal of Controlled Release |
Volume | 220 |
Issue number | A |
Early online date | 23 Oct 2015 |
DOIs | |
Publication status | Published - 28 Dec 2015 |
Keywords
- Drug delivery
- Microneedle poration
- Nail
- Nanoparticles
- Stimulated Raman scattering
Fingerprint
Dive into the research topics of 'Drug delivery into microneedle-porated nails from nanoparticle reservoirs'. Together they form a unique fingerprint.Profiles
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Begona Delgado-Charro
- Department of Life Sciences - Professor
- Centre for Mathematical Biology
- EPSRC Centre for Doctoral Training in Statistical Applied Mathematics (SAMBa)
- Centre for Bioengineering & Biomedical Technologies (CBio)
Person: Research & Teaching, Affiliate staff
Equipment
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Raman confocal microscope RENISHAM INVIA
Material and Chemical Characterisation (MC2)Facility/equipment: Equipment