Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun

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  Establishing an Approach for the Selection and Design of Secondary Structure Mimetics to Antagonise Protein-Protein Interactions

  Mason, J. (PI)

  Engineering and Physical Sciences Research Council

  1/05/15 → 31/12/18

  Project: Research council

  • Peptide 100%
  • Coiled Coil 34%
  • Protein-Protein Interaction 32%
  • Programmed Cell Death 17%
  • Basic Leucine Zipper Transcription Factor 17%

• Iterative Design, Randomisation, Selection, Truncaqtion and Characterisation to Generate Small High Affinity Antagonists of the Activator Protein-1 Motif

  Mason, J. (PI)

  Cancer Research UK

  1/02/15 → 31/08/16

  Project: UK charity

  • Peptide 100%
  • Coiled Coil 40%
  • Protein-Protein Interaction 37%
  • AP-1 Transcription Factor 28%
  • Peptide Library 27%