Double gold-catalysed annulation of indoles by enynones

Stephen J. Heffernan, James P. Tellam, Marine E. Queru, Andrew C. Silvanus, David Benito, Mary F. Mahon, Alan J. Hennessy, Benjamin I. Andrews, David R. Carbery

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The gold-catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles via a double sodium tetrachloroaurate-catalysed process involving a mixture of C[BOND]H activation and alkyne activation modes of promotion. Good yields for the formation of medicinally relevant [6,5,7]-tricyclic indoles are realised.
Original languageEnglish
Pages (from-to)1149-1159
JournalAdvanced Synthesis & Catalysis
Volume355
Issue number6
Early online date9 Apr 2013
DOIs
Publication statusPublished - 15 Apr 2013

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Indoles
Gold
Chemical activation
Alkynes
Sodium

Cite this

Heffernan, S. J., Tellam, J. P., Queru, M. E., Silvanus, A. C., Benito, D., Mahon, M. F., ... Carbery, D. R. (2013). Double gold-catalysed annulation of indoles by enynones. Advanced Synthesis & Catalysis, 355(6), 1149-1159. https://doi.org/10.1002/adsc.201300018

Double gold-catalysed annulation of indoles by enynones. / Heffernan, Stephen J.; Tellam, James P.; Queru, Marine E.; Silvanus, Andrew C.; Benito, David; Mahon, Mary F.; Hennessy, Alan J.; Andrews, Benjamin I.; Carbery, David R.

In: Advanced Synthesis & Catalysis, Vol. 355, No. 6, 15.04.2013, p. 1149-1159.

Research output: Contribution to journalArticle

Heffernan, SJ, Tellam, JP, Queru, ME, Silvanus, AC, Benito, D, Mahon, MF, Hennessy, AJ, Andrews, BI & Carbery, DR 2013, 'Double gold-catalysed annulation of indoles by enynones', Advanced Synthesis & Catalysis, vol. 355, no. 6, pp. 1149-1159. https://doi.org/10.1002/adsc.201300018
Heffernan SJ, Tellam JP, Queru ME, Silvanus AC, Benito D, Mahon MF et al. Double gold-catalysed annulation of indoles by enynones. Advanced Synthesis & Catalysis. 2013 Apr 15;355(6):1149-1159. https://doi.org/10.1002/adsc.201300018
Heffernan, Stephen J. ; Tellam, James P. ; Queru, Marine E. ; Silvanus, Andrew C. ; Benito, David ; Mahon, Mary F. ; Hennessy, Alan J. ; Andrews, Benjamin I. ; Carbery, David R. / Double gold-catalysed annulation of indoles by enynones. In: Advanced Synthesis & Catalysis. 2013 ; Vol. 355, No. 6. pp. 1149-1159.
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