Double gold-catalysed annulation of indoles by enynones

Stephen J. Heffernan, James P. Tellam, Marine E. Queru, Andrew C. Silvanus, David Benito, Mary F. Mahon, Alan J. Hennessy, Benjamin I. Andrews, David R. Carbery

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34 Citations (Scopus)

Abstract

The gold-catalysed double functionalisation of indoles is presented. Enynones are used to annulate indoles via a double sodium tetrachloroaurate-catalysed process involving a mixture of C[BOND]H activation and alkyne activation modes of promotion. Good yields for the formation of medicinally relevant [6,5,7]-tricyclic indoles are realised.
Original languageEnglish
Pages (from-to)1149-1159
JournalAdvanced Synthesis & Catalysis
Volume355
Issue number6
Early online date9 Apr 2013
DOIs
Publication statusPublished - 15 Apr 2013

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    Heffernan, S. J., Tellam, J. P., Queru, M. E., Silvanus, A. C., Benito, D., Mahon, M. F., Hennessy, A. J., Andrews, B. I., & Carbery, D. R. (2013). Double gold-catalysed annulation of indoles by enynones. Advanced Synthesis & Catalysis, 355(6), 1149-1159. https://doi.org/10.1002/adsc.201300018