Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease

I. Leroi, M. Barraclough, S. Mckie, N. Hinvest, J. Evans, R. Elliott, K. Mcdonald

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The development of impulse control disorders (ICDs) in Parkinson's disease (PD) may arise from an interaction among cognitive impairment, impulsive responding and dopaminergic state. Dopaminergic state may be influenced by pharmacologic or genotypic (catechol-O-methyltransferase; COMT) factors. We sought to investigate this interaction further by comparing those with (n = 35) and without (n = 55) ICDs on delay-discounting in different pharmacologic conditions (ON or OFF dopaminergic medication) and on response inhibition as well as aspects of executive functioning in the ON state. We then undertook an exploratory sub-group analysis of these same tasks when the overall PD group was divided into different allelic variants of COMT (val/val vs. met/met). A healthy control group (HC; n = 20) was also included. We found that in those with PD and ICDs, 'cognitive flexibility' (set shifting, verbal fluency, and attention) in the ON medication state was not impaired compared with those without ICDs. In contrast, our working memory, or 'cognitive focus', task was impaired in both PD groups compared with the HC group when ON. During the delay-discounting task, the PD with ICDs group expressed greater impulsive choice compared with the PD group without ICDs, when in the ON, but not the OFF, medication state. However, no group difference on the response inhibition task was seen when ON. Finally, the met homozygous group performed differently on tests of executive function compared with the val homozygous group. We concluded that the disparity in levels of impairment among different domains of executive function and impulsive decision-making distinguishes those with ICD in PD from those without ICD, and may in part be affected by dopaminergic status. Both pharmacologic and genotypic influences on dopaminergic state may be important in ICD.
Original languageEnglish
Pages (from-to)306-325
Number of pages20
JournalJournal of Neuropsychology
Volume7
Issue number2
Early online date31 Jul 2013
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Disruptive, Impulse Control, and Conduct Disorders
Impulsive Behavior
Executive Function
Parkinson Disease
Catechol O-Methyltransferase
Control Groups
Short-Term Memory
Decision Making

Cite this

Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease. / Leroi, I.; Barraclough, M.; Mckie, S.; Hinvest, N.; Evans, J.; Elliott, R.; Mcdonald, K.

In: Journal of Neuropsychology, Vol. 7, No. 2, 09.2013, p. 306-325.

Research output: Contribution to journalArticle

Leroi, I. ; Barraclough, M. ; Mckie, S. ; Hinvest, N. ; Evans, J. ; Elliott, R. ; Mcdonald, K. / Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease. In: Journal of Neuropsychology. 2013 ; Vol. 7, No. 2. pp. 306-325.
@article{19e6ee0822e84746a6c5f239a5ee94c5,
title = "Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease",
abstract = "The development of impulse control disorders (ICDs) in Parkinson's disease (PD) may arise from an interaction among cognitive impairment, impulsive responding and dopaminergic state. Dopaminergic state may be influenced by pharmacologic or genotypic (catechol-O-methyltransferase; COMT) factors. We sought to investigate this interaction further by comparing those with (n = 35) and without (n = 55) ICDs on delay-discounting in different pharmacologic conditions (ON or OFF dopaminergic medication) and on response inhibition as well as aspects of executive functioning in the ON state. We then undertook an exploratory sub-group analysis of these same tasks when the overall PD group was divided into different allelic variants of COMT (val/val vs. met/met). A healthy control group (HC; n = 20) was also included. We found that in those with PD and ICDs, 'cognitive flexibility' (set shifting, verbal fluency, and attention) in the ON medication state was not impaired compared with those without ICDs. In contrast, our working memory, or 'cognitive focus', task was impaired in both PD groups compared with the HC group when ON. During the delay-discounting task, the PD with ICDs group expressed greater impulsive choice compared with the PD group without ICDs, when in the ON, but not the OFF, medication state. However, no group difference on the response inhibition task was seen when ON. Finally, the met homozygous group performed differently on tests of executive function compared with the val homozygous group. We concluded that the disparity in levels of impairment among different domains of executive function and impulsive decision-making distinguishes those with ICD in PD from those without ICD, and may in part be affected by dopaminergic status. Both pharmacologic and genotypic influences on dopaminergic state may be important in ICD.",
author = "I. Leroi and M. Barraclough and S. Mckie and N. Hinvest and J. Evans and R. Elliott and K. Mcdonald",
year = "2013",
month = "9",
doi = "10.1111/jnp.12026",
language = "English",
volume = "7",
pages = "306--325",
journal = "Journal of Neuropsychology",
issn = "1748-6645",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Dopaminergic influences on executive function and impulsive behaviour in impulse control disorders in Parkinson's disease

AU - Leroi, I.

AU - Barraclough, M.

AU - Mckie, S.

AU - Hinvest, N.

AU - Evans, J.

AU - Elliott, R.

AU - Mcdonald, K.

PY - 2013/9

Y1 - 2013/9

N2 - The development of impulse control disorders (ICDs) in Parkinson's disease (PD) may arise from an interaction among cognitive impairment, impulsive responding and dopaminergic state. Dopaminergic state may be influenced by pharmacologic or genotypic (catechol-O-methyltransferase; COMT) factors. We sought to investigate this interaction further by comparing those with (n = 35) and without (n = 55) ICDs on delay-discounting in different pharmacologic conditions (ON or OFF dopaminergic medication) and on response inhibition as well as aspects of executive functioning in the ON state. We then undertook an exploratory sub-group analysis of these same tasks when the overall PD group was divided into different allelic variants of COMT (val/val vs. met/met). A healthy control group (HC; n = 20) was also included. We found that in those with PD and ICDs, 'cognitive flexibility' (set shifting, verbal fluency, and attention) in the ON medication state was not impaired compared with those without ICDs. In contrast, our working memory, or 'cognitive focus', task was impaired in both PD groups compared with the HC group when ON. During the delay-discounting task, the PD with ICDs group expressed greater impulsive choice compared with the PD group without ICDs, when in the ON, but not the OFF, medication state. However, no group difference on the response inhibition task was seen when ON. Finally, the met homozygous group performed differently on tests of executive function compared with the val homozygous group. We concluded that the disparity in levels of impairment among different domains of executive function and impulsive decision-making distinguishes those with ICD in PD from those without ICD, and may in part be affected by dopaminergic status. Both pharmacologic and genotypic influences on dopaminergic state may be important in ICD.

AB - The development of impulse control disorders (ICDs) in Parkinson's disease (PD) may arise from an interaction among cognitive impairment, impulsive responding and dopaminergic state. Dopaminergic state may be influenced by pharmacologic or genotypic (catechol-O-methyltransferase; COMT) factors. We sought to investigate this interaction further by comparing those with (n = 35) and without (n = 55) ICDs on delay-discounting in different pharmacologic conditions (ON or OFF dopaminergic medication) and on response inhibition as well as aspects of executive functioning in the ON state. We then undertook an exploratory sub-group analysis of these same tasks when the overall PD group was divided into different allelic variants of COMT (val/val vs. met/met). A healthy control group (HC; n = 20) was also included. We found that in those with PD and ICDs, 'cognitive flexibility' (set shifting, verbal fluency, and attention) in the ON medication state was not impaired compared with those without ICDs. In contrast, our working memory, or 'cognitive focus', task was impaired in both PD groups compared with the HC group when ON. During the delay-discounting task, the PD with ICDs group expressed greater impulsive choice compared with the PD group without ICDs, when in the ON, but not the OFF, medication state. However, no group difference on the response inhibition task was seen when ON. Finally, the met homozygous group performed differently on tests of executive function compared with the val homozygous group. We concluded that the disparity in levels of impairment among different domains of executive function and impulsive decision-making distinguishes those with ICD in PD from those without ICD, and may in part be affected by dopaminergic status. Both pharmacologic and genotypic influences on dopaminergic state may be important in ICD.

UR - http://www.scopus.com/inward/record.url?scp=84880883408&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1111/jnp.12026

U2 - 10.1111/jnp.12026

DO - 10.1111/jnp.12026

M3 - Article

VL - 7

SP - 306

EP - 325

JO - Journal of Neuropsychology

JF - Journal of Neuropsychology

SN - 1748-6645

IS - 2

ER -