Doing the unexpected: proteins involved in hydrogen peroxide perception

J Hancock, R Desikan, J Harrison, J Bright, R Hooley, S Neill

Research output: Contribution to journalArticle

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Abstract

A look back at the early literature on reactive oxygen species (ROS) gives the impression that these small inorganic molecules had a singular defined role, that of host defence in mammalian systems. However, it is now known that their roles also include a major part in cell signalling, in a broad range of organisms from mammals to plants. Similarly, a look back at papers on the proteins now thought to be involved in the perception of hydrogen peroxide (H2O2) Will show that they too had defined functions assigned to them, completely independent to H2O2 signalling. These proteins have disparate roles, in ethylene perception or even major metabolic pathways such as glycolysis. However, the chemistry of H2O2 sensing dictates that the proteins have a commonality, with active thiol groups being potential ROS targets. The challenge now is to determine the full range of proteins which may partake in the role of H2O2 perception, and to determine the mechanisms by which the signal is transmitted to the next players in the signal transduction pathways.
LanguageEnglish
Pages1711-1718
Number of pages8
JournalJournal of Experimental Botany
Volume57
Issue number8
DOIs
StatusPublished - 2006

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Hydrogen Peroxide
hydrogen peroxide
reactive oxygen species
Reactive Oxygen Species
Proteins
proteins
glycolysis
Glycolysis
Metabolic Networks and Pathways
thiols
Sulfhydryl Compounds
signal transduction
biochemical pathways
Mammals
ethylene
Signal Transduction
chemistry
mammals
organisms
cells

Cite this

Hancock, J., Desikan, R., Harrison, J., Bright, J., Hooley, R., & Neill, S. (2006). Doing the unexpected: proteins involved in hydrogen peroxide perception. DOI: 10.1093/jxb/erj180

Doing the unexpected: proteins involved in hydrogen peroxide perception. / Hancock, J; Desikan, R; Harrison, J; Bright, J; Hooley, R; Neill, S.

In: Journal of Experimental Botany, Vol. 57, No. 8, 2006, p. 1711-1718.

Research output: Contribution to journalArticle

Hancock, J, Desikan, R, Harrison, J, Bright, J, Hooley, R & Neill, S 2006, 'Doing the unexpected: proteins involved in hydrogen peroxide perception' Journal of Experimental Botany, vol. 57, no. 8, pp. 1711-1718. DOI: 10.1093/jxb/erj180
Hancock J, Desikan R, Harrison J, Bright J, Hooley R, Neill S. Doing the unexpected: proteins involved in hydrogen peroxide perception. Journal of Experimental Botany. 2006;57(8):1711-1718. Available from, DOI: 10.1093/jxb/erj180
Hancock, J ; Desikan, R ; Harrison, J ; Bright, J ; Hooley, R ; Neill, S. / Doing the unexpected: proteins involved in hydrogen peroxide perception. In: Journal of Experimental Botany. 2006 ; Vol. 57, No. 8. pp. 1711-1718
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