DNA–polymer conjugates via the graft-through polymerisation of native DNA in water

Lucy A. Arkinstall; Jonathan T. Husband; Thomas R. Wilks; Jeffrey C. Foster; Rachel K. O'Reilly

doi:10.1039/d0cc08008j

DNA–polymer conjugates via the graft-through polymerisation of native DNA in water

Lucy A. Arkinstall, Jonathan T. Husband, Thomas R. Wilks, Jeffrey C. Foster, Rachel K. O'Reilly

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

Abstract

The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.

Original language	English
Pages (from-to)	5466-5469
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	44
DOIs	https://doi.org/10.1039/d0cc08008j
Publication status	Published - 24 Apr 2021

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10.1039/d0cc08008jLicence: CC BY-NC

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title = "DNA–polymer conjugates via the graft-through polymerisation of native DNA in water",

abstract = "The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.",

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AU - Arkinstall, Lucy A.

AU - Husband, Jonathan T.

AU - Wilks, Thomas R.

AU - Foster, Jeffrey C.

AU - O'Reilly, Rachel K.

PY - 2021/4/24

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N2 - The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.

AB - The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.

U2 - 10.1039/d0cc08008j

DO - 10.1039/d0cc08008j

M3 - Article

SN - 1359-7345

VL - 57

SP - 5466

EP - 5469

JO - Chemical Communications

JF - Chemical Communications

IS - 44

ER -

DNA–polymer conjugates via the graft-through polymerisation of native DNA in water

Abstract

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