TY - JOUR
T1 - DNA as a target for antimicrobials
AU - Bolhuis, Albert
AU - Aldrich-Wright, Janice R.
PY - 2014/8
Y1 - 2014/8
N2 - Resistance to antimicrobials is one of the biggest threats to our healthcare. However, in the last few decades very few truly novel antimicrobial compounds have been brought to market, creating the potential threat of a post-antibiotic era in which infections are very difficult to treat. Identification of novel compounds with antimicrobial activity is therefore paramount. Ideally, novel compounds should be designed that are active against targets that are not or barely used, as it is less likely that resistance already exists against such compounds. One example of an underexplored target in the treatment of infections is DNA. In this review we describe a number of DNA binding compounds and discuss potential opportunities and problems.
AB - Resistance to antimicrobials is one of the biggest threats to our healthcare. However, in the last few decades very few truly novel antimicrobial compounds have been brought to market, creating the potential threat of a post-antibiotic era in which infections are very difficult to treat. Identification of novel compounds with antimicrobial activity is therefore paramount. Ideally, novel compounds should be designed that are active against targets that are not or barely used, as it is less likely that resistance already exists against such compounds. One example of an underexplored target in the treatment of infections is DNA. In this review we describe a number of DNA binding compounds and discuss potential opportunities and problems.
UR - http://www.scopus.com/inward/record.url?scp=84897968550&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/j.bioorg.2014.03.009
U2 - 10.1016/j.bioorg.2014.03.009
DO - 10.1016/j.bioorg.2014.03.009
M3 - Article
SN - 0045-2068
VL - 55
SP - 51
EP - 59
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
ER -