Projects per year
Abstract
Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response by lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-κB and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38.
Original language | English |
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Pages (from-to) | 396-406 |
Number of pages | 11 |
Journal | FEBS Letters |
Volume | 589 |
Issue number | 3 |
Early online date | 29 Dec 2014 |
DOIs | |
Publication status | Published - 30 Jan 2015 |
Keywords
- Enhancer RNA
- ERK and p38
- Lipopolysaccharide
- Long non-coding RNA
- Monocyte
- NF-κB
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Dive into the research topics of 'Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells'. Together they form a unique fingerprint.Projects
- 1 Finished
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Are Long Intergenic Non-ccoding RNAs Central Regulators of Inflammation and the Innate Immune Response?
Biotechnology and Biological Sciences Research Council
3/04/13 → 2/04/16
Project: Research council
Profiles
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Mark Lindsay
- Department of Life Sciences - Director of Research and Knowledge Exchange
- Centre for Therapeutic Innovation
Person: Research & Teaching