Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells

James A. Heward, Benoit T. Roux, Mark A. Lindsay

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
132 Downloads (Pure)

Abstract

Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response by lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-κB and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38.

Original languageEnglish
Pages (from-to)396-406
Number of pages11
JournalFEBS Letters
Volume589
Issue number3
Early online date29 Dec 2014
DOIs
Publication statusPublished - 30 Jan 2015

Keywords

  • Enhancer RNA
  • ERK and p38
  • Lipopolysaccharide
  • Long non-coding RNA
  • Monocyte
  • NF-κB

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