Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)

M. Li, H. Ge, R.L. Arrowsmith, V. Mirabello, S.W. Botchway, W. Zhu, S.I. Pascu, T.D. James

Research output: Contribution to journalArticlepeer-review

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Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu2 selective fluorescent sensor in living cells. This derivative is one of the rare examples of reversible fluorescent chemosensors for Cu2  which uses a boronic acid group for a binding site. Moreover, the adduct BNP-Cu2 displays a fluorescence enhancement with fructose. The uptake of this novel compound in HeLa cancer cells was imaged using confocal fluorescence microscopy techniques including two-photon fluorescence lifetime imaging microscopy.

Original languageEnglish
Pages (from-to)11806-11809
Number of pages4
JournalChemical Communications
Issue number80
Early online date4 Jun 2014
Publication statusPublished - 14 Oct 2014


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