Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)

M. Li, H. Ge, R.L. Arrowsmith, V. Mirabello, S.W. Botchway, W. Zhu, S.I. Pascu, T.D. James

Research output: Contribution to journalArticle

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Abstract

Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu2 selective fluorescent sensor in living cells. This derivative is one of the rare examples of reversible fluorescent chemosensors for Cu2  which uses a boronic acid group for a binding site. Moreover, the adduct BNP-Cu2 displays a fluorescence enhancement with fructose. The uptake of this novel compound in HeLa cancer cells was imaged using confocal fluorescence microscopy techniques including two-photon fluorescence lifetime imaging microscopy.

LanguageEnglish
Pages11806-11809
Number of pages4
JournalChemical Communications
Volume50
Issue number80
Early online date4 Jun 2014
DOIs
StatusPublished - 14 Oct 2014

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Naphthalimides
Boronic Acids
Imines
Copper
Bearings (structural)
Fluorescence
Cells
Derivatives
Fructose
Acids
Confocal microscopy
Fluorescence microscopy
Sensors
Binding sites
Microscopic examination
Photons
Display devices
Binding Sites
Ions
Imaging techniques

Cite this

Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii). / Li, M.; Ge, H.; Arrowsmith, R.L.; Mirabello, V.; Botchway, S.W.; Zhu, W.; Pascu, S.I.; James, T.D.

In: Chemical Communications, Vol. 50, No. 80, 14.10.2014, p. 11806-11809.

Research output: Contribution to journalArticle

Li, M. ; Ge, H. ; Arrowsmith, R.L. ; Mirabello, V. ; Botchway, S.W. ; Zhu, W. ; Pascu, S.I. ; James, T.D. / Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii). In: Chemical Communications. 2014 ; Vol. 50, No. 80. pp. 11806-11809.
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