Dissociating breathlessness symptoms from mood in asthma

Olivia K. Harrison, Lucy Marlow, Sarah Finnegan, Ben Ainsworth, Kyle Pattinson

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10 Citations (SciVal)

Abstract

It is poorly understood why asthma symptoms are often discordant with objective medical tests. Differences in interoception (perception of internal bodily processes) may help explain symptom discordance, which may be further influenced by mood and attention. We explored inter-relationships between interoception, mood and attention in 63 individuals with asthma and 30 controls. Questionnaires, a breathing-related interoception task, two attention tasks, and standard clinical assessments were performed. Questionnaires were analysed using exploratory factor analysis, and linear regression examined relationships between measures. K-means clustering also defined asthma subgroups. Two concordant asthma subgroups (symptoms related appropriately to pathophysiology, normal mood) and one discordant subgroup (moderate symptoms, minor pathophysiology, low mood) were found. In all participants, negative mood correlated with decreased interoceptive ability and faster reaction times in an attention task. Our findings suggest that interpreting bodily sensations relates to mood, and this effect may be heightened in subgroups of individuals with asthma.
Original languageEnglish
Article number108193
JournalBiological Psychology
Volume165
Early online date22 Sept 2021
DOIs
Publication statusPublished - 31 Oct 2021

Funding

The study was funded by the JABBS Foundation. OKH (n?e Faull) was supported as a Marie Sk?odowska-Curie Postdoctoral Fellow from the European Union's Horizon 2020 Research and Innovation Programme (under the Grant Agreement no. 793580), and as a Rutherford Discovery Fellow from the Royal Society of New Zealand. SLF and KP was supported by the Dunhill Medical Trust (Grant R333/0214) and the National Institute for Health Research Biomedical Research Centre based at Oxford University Hospitals NHS Foundation Trust and The University of Oxford (Grant RCF18/002)". The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z). The study was funded by the JABBS Foundation . OKH (née Faull) was supported as a Marie Skłodowska-Curie Postdoctoral Fellow from the European Union’s Horizon 2020 Research and Innovation Programme (under the Grant Agreement no. 793580 ), and as a Rutherford Discovery Fellow from the Royal Society of New Zealand . SLF and KP was supported by the Dunhill Medical Trust (Grant R333/0214 ) and the National Institute for Health Research Biomedical Research Centre based at Oxford University Hospitals NHS Foundation Trust and The University of Oxford (Grant RCF18/002 )". The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust ( 203139/Z/16/Z ).

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