TY - JOUR
T1 - Dissecting the immune response to the entomopathogen Photorhabdus
AU - Eleftherianos, I
AU - Ffrench-Constant, R H
AU - Clarke, D J
AU - Dowling, A J
AU - Reynolds, Stuart E
PY - 2010/12
Y1 - 2010/12
N2 - Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens
AB - Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens
UR - http://www.scopus.com/inward/record.url?scp=78649326176&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/j.tim.2010.09.006
U2 - 10.1016/j.tim.2010.09.006
DO - 10.1016/j.tim.2010.09.006
M3 - Article
SN - 0966-842X
VL - 18
SP - 552
EP - 560
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 12
ER -