Dissecting the immune response to the entomopathogen Photorhabdus

I Eleftherianos, R H Ffrench-Constant, D J Clarke, A J Dowling, Stuart E Reynolds

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Abstract

Bacterial pathogens either hide from or modulate the host's immune response to ensure their survival Photorhabdus is a potent insect pathogenic bacterium that uses entomopathogenic nematodes as vectors in a system that represents a useful tool for probing the molecular basis of immunity During the course of infection, Photorhabdus multiplies rapidly within the insect, producing a range of toxins that inhibit phagocytosis of the invading bacteria and eventually kill the insect host Photorhabdus bacteria have recently been established as a tool for investigating immune recognition and defense mechanisms in model hosts such as Manduca and Drosophila Such studies pave the way for investigations of gene interactions between pathogen virulence factors and host immune genes, which ultimately could lead to an understanding of how some Photorhabdus species have made the leap to becoming human pathogens
Original languageEnglish
Pages (from-to)552-560
Number of pages9
JournalTrends in Microbiology
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2010

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Photorhabdus
Insects
Bacteria
Manduca
Virulence Factors
Phagocytosis
Genes
Drosophila
Immunity
Survival
Infection

Cite this

Eleftherianos, I., Ffrench-Constant, R. H., Clarke, D. J., Dowling, A. J., & Reynolds, S. E. (2010). Dissecting the immune response to the entomopathogen Photorhabdus. Trends in Microbiology, 18(12), 552-560. https://doi.org/10.1016/j.tim.2010.09.006

Dissecting the immune response to the entomopathogen Photorhabdus. / Eleftherianos, I; Ffrench-Constant, R H; Clarke, D J; Dowling, A J; Reynolds, Stuart E.

In: Trends in Microbiology, Vol. 18, No. 12, 12.2010, p. 552-560.

Research output: Contribution to journalArticle

Eleftherianos, I, Ffrench-Constant, RH, Clarke, DJ, Dowling, AJ & Reynolds, SE 2010, 'Dissecting the immune response to the entomopathogen Photorhabdus', Trends in Microbiology, vol. 18, no. 12, pp. 552-560. https://doi.org/10.1016/j.tim.2010.09.006
Eleftherianos, I ; Ffrench-Constant, R H ; Clarke, D J ; Dowling, A J ; Reynolds, Stuart E. / Dissecting the immune response to the entomopathogen Photorhabdus. In: Trends in Microbiology. 2010 ; Vol. 18, No. 12. pp. 552-560.
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