Displaying the relatedness among isolates of bacterial species - the eBURST approach

B G Spratt, W P Hanage, B Li, D M Aanensen, E J Feil

Research output: Contribution to journalArticlepeer-review

163 Citations (SciVal)

Abstract

Determining the most appropriate way to represent the relationships between bacterial isolates is complicated by the differing rates of recombination within species. In many cases, a bifurcating tree can be positively misleading. The recently described program eBURST can be used with multilocus data to define groups or clonal complexes of related isolates derived from a common ancestor, the patterns of descent linking them together, and the ancestral genotype. eBURST has recently been extensively updated to include additional tools for exploring the relationships between isolates. We discuss the advantages of this approach and describe its use to explore patterns of descent within clonal complexes identified using multilocus sequence typing. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalFEMS Microbiology Letters
Volume241
Issue number2
DOIs
Publication statusPublished - 2004

Bibliographical note

ID number: ISI:000226174000001

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