Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer’s Disease Therapy

Pharmacology, Toxicology and Pharmaceutical Science

• Alzheimer's Disease 100%
• Combination Therapy 100%
• Acetylcholinesterase 100%
• Amyloid Protein 50%
• Oligomer 50%
• IC50 33%
• Neuroprotective Agent 16%
• Neurotoxicity 16%
• Antioxidant Capacity 16%
• Lead Compound 16%
• Liver Enzyme 16%
• Neurologic Disease 16%

Chemistry

• Oligomer 100%
• IC50 66%
• Reactive Oxygen Species 33%
• Neuroprotective 33%
• Antioxidant Capacity 33%
• Protective 33%
• Inhibitory Concentration 33%
• Haematological 33%
• Neurotoxicity 33%
• Lead Compound 33%