Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2or imidazole as catalysts

A. Rosie Chhatwal; Helen V. Lomax; A. John Blacker; Jonathan M.J. Williams; Patricia Marcé

doi:10.1039/d0sc01317j

Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO₃)₂or imidazole as catalysts

A. Rosie Chhatwal
, Helen V. Lomax
, A. John Blacker
, Jonathan M.J. Williams
, Patricia Marcé

Department of Chemistry

University of Leeds

Research output: Contribution to journal › Article › peer-review

40 Citations (SciVal)

Abstract

A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO₃)₂·6H₂O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.

Original language	English
Pages (from-to)	5808-5818
Number of pages	11
Journal	Chemical Science
Volume	11
Issue number	22
Early online date	19 May 2020
DOIs	https://doi.org/10.1039/d0sc01317j
Publication status	Published - 14 Jun 2020

Acknowledgements

We would also like to acknowledge the NMR and MS facilities provided through the Material and Chemical Characterisation (MC2) at the University of Bath.

Funding

We would like to thank the EPSRC for funding through the UK Catalysis Hub and the Doctoral Training Centre in Sustainable Chemical Technologies for studentship (H. V. L.).

Funders
Engineering and Physical Sciences Research Council

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1039/d0sc01317jLicence: CC BY

Cite this

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AU - Marcé, Patricia

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