Direct amide formation from unactivated carboxylic acids and amines

C Liana Allen; A Rosie Chhatwal; Jonathan M J Williams

doi:10.1039/c1cc15210f

Direct amide formation from unactivated carboxylic acids and amines

C Liana Allen, A Rosie Chhatwal, Jonathan M J Williams

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

269 Citations (SciVal)

Abstract

The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 degrees C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.

Original language	English
Pages (from-to)	666-668
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	5
DOIs	https://doi.org/10.1039/c1cc15210f
Publication status	Published - 2012

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10.1039/c1cc15210f

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title = "Direct amide formation from unactivated carboxylic acids and amines",

abstract = "The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 degrees C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.",

author = "Allen, {C Liana} and Chhatwal, {A Rosie} and Williams, {Jonathan M J}",

year = "2012",

doi = "10.1039/c1cc15210f",

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pages = "666--668",

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AU - Allen, C Liana

AU - Chhatwal, A Rosie

AU - Williams, Jonathan M J

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AB - The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 degrees C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.

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UR - http://dx.doi.org/10.1039/c1cc15210f

U2 - 10.1039/c1cc15210f

DO - 10.1039/c1cc15210f

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JO - Chemical communications (Cambridge, England)

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Direct amide formation from unactivated carboxylic acids and amines

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Direct amide formation from unactivated carboxylic acids and amines

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