Direct amide formation from unactivated carboxylic acids and amines

C Liana Allen, A Rosie Chhatwal, Jonathan M J Williams

Research output: Contribution to journalArticlepeer-review

228 Citations (Scopus)

Abstract

The direct coupling of unactivated carboxylic acids with amines can be performed in toluene 110 degrees C in the absence of catalyst. The use of simple zirconium catalysts at 5 mol% loading gave amide formation in as little as 4 h.
Original languageEnglish
Pages (from-to)666-668
Number of pages3
JournalChemical Communications
Volume48
Issue number5
DOIs
Publication statusPublished - 2012

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