dino and mercedes, two genes regulating dorsal development in the zebrafish embryo

M Hammerschmidt, F Pelegri, M C Mullins, D A Kane, F J M vanEeden, M Granato, M Brand, Makoto Furutani-Seiki, P Haffter, C P Heisenberg, Y J Jiang, R N Kelsh, J Odenthal, R M Warga, C NussleinVolhard

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304 Citations (SciVal)


We describe two genes, dino and mercedes, which are required for the organization of the zebrafish body plan, In dine mutant embryos, the tail is enlarged at the expense of the head and the anterior region of the trunk, The altered expression patterns of various marker genes reveal that, with the exception of the dorsal most marginal zone, all regions of the early dine mutant embryo acquire more ventral fates, These alterations are already apparent before the onset of gastrulation, mercedes mutant embryos show a similar but weaker phenotype, suggesting a role in the same patterning processes. The phenotypes suggests that dine and mercedes are required for the establishment of dorsal fates in both the marginal and the animal zone of the early gastrula embryo, Their function in the patterning of the ventrolateral mesoderm and the induction of the neuroectoderm is similar to the function of the Spemann organizer in the amphibian embryo.
Original languageEnglish
Pages (from-to)95-102
Number of pages8
Publication statusPublished - 1996


  • mesoderm patterning
  • dino
  • neural induction
  • dorsalization
  • zebrafish
  • mercedes


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