Differential effects of acute and chronic nicotine on Elk-I in rat hippocampus

S Nuutinen, J Barik, I W Jones, S Wonnacott

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Transcriptional regulation is central to the long-term effects of drugs of abuse. Activation of the extracellular signal-regulated kinase (ERK1/2) pathway underlies plasticity changes that accompany drug use. One target of ERK1/2 activation is the Ets-like transcription factor Elk-I. We show here that nicotine modulates Elk-I in the rat hippocampus in a spatially and temporally specific manner. In-vitro nicotine (1 mu M) activated Elk-I in hippocampal slices. In-vivo acute nicotine (0.4 mg/kg) activated Elk-I in the CAI area but not in the dentate gyrus. Chronic nicotine for 14 days changed the level of total Elk-I but not its phosphorylation state. Thus, Elk-I regulation of transcriptional events may contribute to nicotine-induced changes in the hippocampus.
Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalNeuroreport
Volume18
Issue number2
DOIs
Publication statusPublished - Jan 2007

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Nicotine
Hippocampus
Proto-Oncogene Proteins c-ets
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase 1
Dentate Gyrus
Street Drugs
Phosphorylation
Pharmaceutical Preparations

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Differential effects of acute and chronic nicotine on Elk-I in rat hippocampus. / Nuutinen, S; Barik, J; Jones, I W; Wonnacott, S.

In: Neuroreport, Vol. 18, No. 2, 01.2007, p. 121-126.

Research output: Contribution to journalArticle

Nuutinen, S ; Barik, J ; Jones, I W ; Wonnacott, S. / Differential effects of acute and chronic nicotine on Elk-I in rat hippocampus. In: Neuroreport. 2007 ; Vol. 18, No. 2. pp. 121-126.
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