Development of metal complexes as potential antimicrobials

Albert Bolhuis, Adair D Richards

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In 1969, the Surgeon General of the USA said that it was time “to close the book on infectious diseases” on the basis of the prolific success of antibiotics in the previous quarter century that had been widely prescribed [1]. This optimism, whilst seemingly justified at the time, was seriously misjudged, as the intervening 40 years have clearly demonstrated. This is because of the previously disregarded ability of bacteria to genetically mutate to an extent where future generations of bacteria proved immune to the effects of specific antibiotics – hence the need for novel approaches to combating microbial infections is as great as ever.
Original languageEnglish
Title of host publicationMetallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules
EditorsJ Aldrich-Wright
Place of PublicationNew York
PublisherSpringer
Pages373-388
Number of pages16
ISBN (Print)978-3-211-09427-3
DOIs
Publication statusPublished - 2011

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    Bolhuis, A., & Richards, A. D. (2011). Development of metal complexes as potential antimicrobials. In J. Aldrich-Wright (Ed.), Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules (pp. 373-388). Springer. https://doi.org/10.1007/978-3-211-99079-7_15