In 1969, the Surgeon General of the USA said that it was time “to close the book on infectious diseases” on the basis of the prolific success of antibiotics in the previous quarter century that had been widely prescribed . This optimism, whilst seemingly justified at the time, was seriously misjudged, as the intervening 40 years have clearly demonstrated. This is because of the previously disregarded ability of bacteria to genetically mutate to an extent where future generations of bacteria proved immune to the effects of specific antibiotics – hence the need for novel approaches to combating microbial infections is as great as ever.
|Title of host publication||Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules|
|Place of Publication||New York|
|Number of pages||16|
|Publication status||Published - 2011|
Bolhuis, A., & Richards, A. D. (2011). Development of metal complexes as potential antimicrobials. In J. Aldrich-Wright (Ed.), Metallointercalators: Synthesis and Techniques to Probe Their Interactions with Biomolecules (pp. 373-388). Springer. https://doi.org/10.1007/978-3-211-99079-7_15