Development of a novel single vessel processor: part 2: particle size reduction characteristics

Objective.: To characterise the effectiveness of a novel Single Vessel Processor (SVP) in reducing the particle size of lactose granules for use in tablet production. Conclusions.Particle size reduction of granular lactose was found to be rapid for the batch size investigated; the speed and extent of size reduction was considered to be at least equivalent to that which could be attained using conventional processing techniques. It is envisaged that greater size reduction of primary crystallites could be obtained by increasing the nozzle air pressures and/or altering the geometry of the novel SVP