TY - JOUR
T1 - Development of a continuous flow reactor for pharmaceuticals using catalytic monoliths
T2 - Pt/C selective oxidation of benzyl alcohol
AU - Al Badran, F.
AU - Awdry, S.
AU - Kolaczkowski, S.T.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - A novel design of pilot-scale continuous flow pharmaceutical fixed-bed catalytic reactor has been developed. This incorporates in a structured manner the use of multiple catalytic monoliths (o.d. = 20 mm; L = 50 mm). O2 was used as the oxidant (O2/N2 mixture) for the partial oxidation of benzyl alcohol to benzaldehyde, using Pt impregnated (2.5 and 2.7 wt%) carbon monoliths. Reactions were performed e.g. at liquid flow = 1 dm 3 h-1; benzyl alcohol concentration = 1 kmol m -3; T = 110 C; P = 12 bar(g). A major breakthrough was the demonstration of the viability of this design at pilot-scale.
AB - A novel design of pilot-scale continuous flow pharmaceutical fixed-bed catalytic reactor has been developed. This incorporates in a structured manner the use of multiple catalytic monoliths (o.d. = 20 mm; L = 50 mm). O2 was used as the oxidant (O2/N2 mixture) for the partial oxidation of benzyl alcohol to benzaldehyde, using Pt impregnated (2.5 and 2.7 wt%) carbon monoliths. Reactions were performed e.g. at liquid flow = 1 dm 3 h-1; benzyl alcohol concentration = 1 kmol m -3; T = 110 C; P = 12 bar(g). A major breakthrough was the demonstration of the viability of this design at pilot-scale.
UR - http://www.scopus.com/inward/record.url?scp=84883742121&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1016/j.cattod.2013.04.017
U2 - 10.1016/j.cattod.2013.04.017
DO - 10.1016/j.cattod.2013.04.017
M3 - Article
SN - 0920-5861
VL - 216
SP - 229
EP - 239
JO - Catalysis Today
JF - Catalysis Today
ER -