Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Roman Mikhaylov; Fangda Wu; Hanlin Wang; Aled Clayton; Chao Sun; Zhihua Xie; Dongfang Liang; Yinhua Dong; Fan Yuan; Despina Moschou; Zhenlin Wu; Ming Hong Shen; Jian Yang; Yongqing Fu; Zhiyong Yang; Christian Burton; Rachel J. Errington; Marie Wiltshire; Xin Yang

doi:10.1039/c9lc01192g

Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Roman Mikhaylov
, Fangda Wu
, Hanlin Wang
, Aled Clayton
, Chao Sun
, Zhihua Xie
, Dongfang Liang
, Yinhua Dong
, Fan Yuan
, Despina Moschou
, Zhenlin Wu
, Ming Hong Shen
, Jian Yang
, Yongqing Fu
, Zhiyong Yang
, Christian Burton
, Rachel J. Errington
, Marie Wiltshire
, Xin Yang

Cardiff University
Northwestern Polytechnical University
University of Cambridge
Tianjin 4th Centre Hospital
Duke University
Dalian University of Technology
Northumbria University
Tianjin University

Research output: Contribution to journal › Article › peer-review

22 Citations (SciVal)

134 Downloads (Pure)

Abstract

Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. In this paper, we develop a novel and simple technology to fabricate a surface acoustic wave (SAW)-based acoustofluidic device by clamping electrodes made using a printed circuit board (PCB) with a piezoelectric substrate. The PCB-based SAW (PCB-SAW) device is systematically characterised and benchmarked with a SAW device made using the conventional photolithography process with the same specifications. Microparticle manipulations such as streaming in droplets and patterning in microchannels were demonstrated in the PCB-SAW device. In addition, the PCB-SAW device was applied as an acoustic tweezer to pattern lung cancer cells to form three or four traces inside the microchannel in a controllable manner. Cell viability of ~97% was achieved after acoustic manipulation using the PCB-SAW device, which proved its ability as a suitable tool for acoustophoretic applications.

Original language	English
Pages (from-to)	1807-1814
Number of pages	8
Journal	Lab on a Chip
Volume	20
Issue number	10
Early online date	14 Apr 2020
DOIs	https://doi.org/10.1039/c9lc01192g
Publication status	Published - 21 May 2020

Funding

The authors would gratefully acknowledge the financial support from EPSRC (EP/P002803/1, EP/P018998/1), EPSRC IAA, Welcome Trust, Global Challenges Research Fund (GCRF), the Royal Society (IEC\NSFC\170142, IE161019), and the Natural Science Foundation of China (NSFC) (Grant No. 51811530310)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Bioengineering
Biochemistry
General Chemistry
Biomedical Engineering

Access to Document

10.1039/c9lc01192g

2019_Mikhaylov_PCB_IDT_CY_DM (2)
© The Royal Society of Chemistry 2020. The final publication is available at Lab on Chip via https://doi.org/10.1039/C9LC01192G
Accepted author manuscript, 536 KB

Cite this

Mikhaylov, R., Wu, F., Wang, H., Clayton, A., Sun, C., Xie, Z., Liang, D., Dong, Y., Yuan, F., Moschou, D., Wu, Z., Shen, M. H., Yang, J., Fu, Y., Yang, Z., Burton, C., Errington, R. J., Wiltshire, M., & Yang, X. (2020). Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip, 20(10), 1807-1814. https://doi.org/10.1039/c9lc01192g

Mikhaylov, R, Wu, F, Wang, H, Clayton, A, Sun, C, Xie, Z, Liang, D, Dong, Y, Yuan, F, Moschou, D, Wu, Z, Shen, MH, Yang, J, Fu, Y, Yang, Z, Burton, C, Errington, RJ, Wiltshire, M & Yang, X 2020, 'Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB', Lab on a Chip, vol. 20, no. 10, pp. 1807-1814. https://doi.org/10.1039/c9lc01192g

@article{2674c5b585eb447289680b0a8c467ab0,

title = "Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB",

abstract = "Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. In this paper, we develop a novel and simple technology to fabricate a surface acoustic wave (SAW)-based acoustofluidic device by clamping electrodes made using a printed circuit board (PCB) with a piezoelectric substrate. The PCB-based SAW (PCB-SAW) device is systematically characterised and benchmarked with a SAW device made using the conventional photolithography process with the same specifications. Microparticle manipulations such as streaming in droplets and patterning in microchannels were demonstrated in the PCB-SAW device. In addition, the PCB-SAW device was applied as an acoustic tweezer to pattern lung cancer cells to form three or four traces inside the microchannel in a controllable manner. Cell viability of \textasciitilde{}97\% was achieved after acoustic manipulation using the PCB-SAW device, which proved its ability as a suitable tool for acoustophoretic applications.",

author = "Roman Mikhaylov and Fangda Wu and Hanlin Wang and Aled Clayton and Chao Sun and Zhihua Xie and Dongfang Liang and Yinhua Dong and Fan Yuan and Despina Moschou and Zhenlin Wu and Shen, \{Ming Hong\} and Jian Yang and Yongqing Fu and Zhiyong Yang and Christian Burton and Errington, \{Rachel J.\} and Marie Wiltshire and Xin Yang",

year = "2020",

month = may,

day = "21",

doi = "10.1039/c9lc01192g",

language = "English",

volume = "20",

pages = "1807--1814",

journal = "Lab on a Chip",

issn = "1473-0197",

publisher = "Royal Society of Chemistry",

number = "10",

}

TY - JOUR

T1 - Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

AU - Mikhaylov, Roman

AU - Wu, Fangda

AU - Wang, Hanlin

AU - Clayton, Aled

AU - Sun, Chao

AU - Xie, Zhihua

AU - Liang, Dongfang

AU - Dong, Yinhua

AU - Yuan, Fan

AU - Moschou, Despina

AU - Wu, Zhenlin

AU - Shen, Ming Hong

AU - Yang, Jian

AU - Fu, Yongqing

AU - Yang, Zhiyong

AU - Burton, Christian

AU - Errington, Rachel J.

AU - Wiltshire, Marie

AU - Yang, Xin

PY - 2020/5/21

Y1 - 2020/5/21

N2 - Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. In this paper, we develop a novel and simple technology to fabricate a surface acoustic wave (SAW)-based acoustofluidic device by clamping electrodes made using a printed circuit board (PCB) with a piezoelectric substrate. The PCB-based SAW (PCB-SAW) device is systematically characterised and benchmarked with a SAW device made using the conventional photolithography process with the same specifications. Microparticle manipulations such as streaming in droplets and patterning in microchannels were demonstrated in the PCB-SAW device. In addition, the PCB-SAW device was applied as an acoustic tweezer to pattern lung cancer cells to form three or four traces inside the microchannel in a controllable manner. Cell viability of ~97% was achieved after acoustic manipulation using the PCB-SAW device, which proved its ability as a suitable tool for acoustophoretic applications.

AB - Acoustofluidics has been increasingly applied in biology, medicine and chemistry due to its versatility in manipulating fluids, cells and nano-/micro-particles. In this paper, we develop a novel and simple technology to fabricate a surface acoustic wave (SAW)-based acoustofluidic device by clamping electrodes made using a printed circuit board (PCB) with a piezoelectric substrate. The PCB-based SAW (PCB-SAW) device is systematically characterised and benchmarked with a SAW device made using the conventional photolithography process with the same specifications. Microparticle manipulations such as streaming in droplets and patterning in microchannels were demonstrated in the PCB-SAW device. In addition, the PCB-SAW device was applied as an acoustic tweezer to pattern lung cancer cells to form three or four traces inside the microchannel in a controllable manner. Cell viability of ~97% was achieved after acoustic manipulation using the PCB-SAW device, which proved its ability as a suitable tool for acoustophoretic applications.

UR - https://www.scopus.com/pages/publications/85084941107

U2 - 10.1039/c9lc01192g

DO - 10.1039/c9lc01192g

M3 - Article

C2 - 32319460

AN - SCOPUS:85084941107

SN - 1473-0197

VL - 20

SP - 1807

EP - 1814

JO - Lab on a Chip

JF - Lab on a Chip

IS - 10

ER -

Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Abstract

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Despina Moschou

Cite this

Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Abstract

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Profiles

Despina Moschou

Cite this