Abstract
The disclosure relates to a computer-implemented method for determining values of biological parameters of a cell, comprising: receiving membrane voltage readings of the cell corresponding to N time points; for a state vector comprising the biological parameters and a plurality of interdependent and time-dependent state variables, including a membrane voltage variable: setting an initial guess of the state vector and parameters; performing an optimization of the state vector by: setting the membrane voltage variable to be equal to a corresponding membrane voltage reading at a number of time points within the N time points; determining an updated value of the state vector by optimizing an objective function that operates on values of the membrane voltage variable and corresponding membrane voltage readings; and repeating the optimization with: the initial estimate of the state vector set to the updated value of the state vector; and the membrane voltage variable set to be equal to a corresponding membrane voltage reading at fewer time points within the N time points.
| Original language | English |
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| Patent number | WO2023/214156 A1 |
| IPC | WO |
| Priority date | 3/05/22 |
| Filing date | 2/05/22 |
| Publication status | Published - 9 Nov 2023 |